Surendra Rajpurohit, PhD, FAHASurendra Rajpurohit, PhD
Research Scientist

Research Summary

Dr. Rajpurohit Lab is working on the Experimental Therapeutic in Glioblastoma and  Cardio-oncology by using in-vivo transparent transgenic zebrafish and mouse model which includes high throughput (HT) drug discovery, repurposing of FDA approved drugs, identification of novel hit and lead drugs, drug validation and drug toxicity in glioblastoma and cardio oncology therapeutics.

Dr. Rajpurohit Lab developing and establishing in-vivo transparent transgenic cellular phenotype model of zebrafish to study of the cell death process (Annexin5 and Inflammatory activity NFkB in the microglia-resident macrophage of the brain and cardiac myocytes. In cardio-oncology, our research is on the development of a transparent transgenic zebrafish model to study Annexin-5 and NF-kB activity in normal and inflamed cardiac myocytes. In glioblastoma research, his lab determines the role of NFkB and microglia function under normal healthy status and in glioblastomas by using mouse and zebrafish model. He is establishing the role of annexin-5 and NF-kB activity in the cardiovascular function under normal and in metabolic aberration by developing homozygous casper/ myl7:RFP; annexin-5:YFP/NF-kB:GFP transgenic zebrafish.

Dr. Rajpurohit designed and established the novel whole organism based ARQiv (automated reporter based quantitative in-vivo HT-screen) platform. This novel devise facilitates large-scale HT drug or chemical screen to find the hit and lead drug for targeted disease module. He has successfully applied this unique platform to screen over 3200 drug candidates to identify novel pathway for increasing pancreatic beta-cell neogenesis and proliferation.

Contact Us

The Rajpurohit Lab

Health Sciences Campus

Georgia Cancer Center - M. Bert Storey Research Building

1410 Laney Walker Blvd, CN 3116A

srajpurohit@augusta.edu

Research Interests

Grants Awarded

Extramural Grant Awarded

Investigator Initiated Grant 2022 (July 2022-July 2025)

 

Foundation Grant: Kirk Kimmerling Foundation 2022 (July 2022-June 2025)

Title of the Project Validation and Toxicology Study of K21 Drug in Zebrafish Model: The grant has been awarded for the project “Validation and Toxicology Study of K21 Drug in Zebrafish Model”.

Augusta University Research and Training Grants Awarded

  1. 2022 CURS Spring Material Grant. Study Title: Generation of Casper/Annexin5 (F05 Homozygous Progeny) Transparent Transgenic Zebrafish Strain to Study Cardiomyocyte Activity
  2. 2021 CURS Fall Material Grant. Study Title: Generation of Casper/Annexin5 (F05 Homozygous Progeny) Transparent Transgenic Zebrafish Strain to Study Cardiomyocyte Activity
  3. 2021 CURS Spring Material Grant. Study Title: Generation of Casper/Annexin5 (F05 Homozygous Progeny) Transparent Transgenic Zebrafish Strain to Study Cardiomyocyte Activity
  4. 2020 CURS Fall Material Grant. Study Title: In-vivo Confocal imaging of newly Developed Homozygous Casper (Transparent skin)-Transgenic Zebrafish Progeny to Study Microglia Function
  5. 2020 CURS Summer Scholars Program Grant. Project Title: Generation of Transparent Transgenic Zebrafish Homozygous Progeny to study the Microglia Function in Health and Disease Status
  6. 2019 CURS Summer Scholars Program Grant. Project Title: Development  of Transparent Transgenic Zebrafish Model to Investigate of Microglia Function.

Research Team

photo of Umasai Kandepu

Umasai Kandepu

  • Medical Scholar
photo of May Ye Mon

May Ye Mon

  • Medical Scholar
photo of Karen Aikhionbare

Karen Aikhionbare

  • Undergraduate/Honors Student
photo of Logan Ouellette

Logan Ouellette

  • Undergraduate/Honors Student
photo of Vaani Balyan

Vaani Balyan

  • Undergraduate/CURS Student
photo of Keshu Bhatt

Keshu Bhatt

  • Undergraduate/CURS Student
photo of Aiden Van Derhei

Aiden Van Derhei

  • Undergraduate/CURS Student
photo of Raymond Chen

Raymond Chen

  • Undergraduate/Honors Student
photo of Taitam Gossman

Taitam Gossman

  • Undergraduate/Honors Student
photo of Sai Nasannly

Sai Nasannly

  • Undergraduate/Honors Student

photo of Aron Gopal, MD

Aron Gopal, MD

photo of Survarsha Sura

Survarsha Sura

photo of Anabelle O’keefe

Anabelle O’keefe

photo of Katherine McCartney

Katherine McCartney

photo of Rohan Kapuria

Rohan Kapuria

photo of Chelsea Appiah

Chelsea Appiah

photo of Aminah Wood

Aminah Wood

photo of Kunal Hotwani

Kunal Hotwani