The Arbab Laboratory

Impact on Patients in Georgia

Glioblastoma remains the most common and aggressive primary malignant brain tumor in adults. Data from the Central Brain Tumor Registry of the United States (CBTRUS) and regional studies indicate that the incidence of GBM in Georgia and South Carolina mirrors trends observed throughout the southeastern United States.

A statewide study in Georgia reported an annual age-standardized incidence rate of 10.62 per 100,000 for all primary brain tumors, with glioblastoma representing the most common malignant subtype. Recent analyses suggest a gradual increase in GBM incidence across the region. 

Importantly, our exosome- and nanoparticle-based delivery platforms are highly adaptable and can be redirected to other cancer types through incorporation of disease-specific targeting ligands. One important application is breast cancer, which continues to represent a major public health burden in both Georgia and South Carolina. Recent state cancer statistics indicate annual breast cancer incidence rates of approximately 130–136 cases per 100,000 women, accounting for thousands of new diagnoses each year. Incidence rates continue to rise, particularly among younger women, while significant racial disparities persist, with higher mortality rates observed among Black women despite lower incidence compared with White women.