Vascular Biology Center Publications

Recent Publications from VBC Faculty:

Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche.

Liu Z, Xu J, Ma Q, Zhang X, Yang Q, Wang L, Cao Y, Xu Z, Tawfik A, Sun Y, Weintraub NL, Fulton DJ, Hong M, Dong Z, Smith LEH, Caldwell RB, Sodhi A, Huo Y.Sci Transl Med. 2020 Aug 5;12(555):eaay1371. doi: 10.1126/scitranslmed.aay1371.PMID: 32759274

 

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.

Cao Y, Zhang X, Wang L, Yang Q, Ma Q, Xu J, Wang J, Kovacs L, Ayon RJ, Liu Z, Zhang M, Zhou Y, Zeng X, Xu Y, Wang Y, Fulton DJ, Weintraub NL, Lucas R, Dong Z, Yuan JX, Sullivan JC, Meadows L, Barman SA, Wu C, Quan J, Hong M, Su Y, Huo Y.Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13394-13403. doi: 10.1073/pnas.1821401116. Epub 2019 Jun 18.PMID: 31213542 

 

Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: Role of MicroRNA-125b.

Sudhahar V, Das A, Horimatsu T, Ash D, Leanhart S, Antipova O, Vogt S, Singla B, Csanyi G, White J, Kaplan JH, Fulton D, Weintraub NL, Kim HW, Ushio-Fukai M, Fukai T.Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2320-2337. doi: 10.1161/ATVBAHA.119.313374. Epub 2019 Sep 26.PMID: 31554420

 

PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis.

Yang Q, Xu J, Ma Q, Liu Z, Sudhahar V, Cao Y, Wang L, Zeng X, Zhou Y, Zhang M, Xu Y, Wang Y, Weintraub NL, Zhang C, Fukai T, Wu C, Huang L, Han Z, Wang T, Fulton DJ, Hong M, Huo Y.Nat Commun. 2018 Nov 7;9(1):4667. doi: 10.1038/s41467-018-07132-x.PMID: 30405100

 

Perivascular Adipose Tissue and Vascular Perturbation/Atherosclerosis.

Won Kim H, Shi H, Winkler MA, Lee R, Weintraub NL.Arterioscler Thromb Vasc Biol. 2020 Sep 3:ATVBAHA120312470. doi: 10.1161/ATVBAHA.120.312470. Online ahead of print.PMID: 32878476

 

Perivascular Adipose Tissue and Vascular Perturbation/Atherosclerosis.

Won Kim H, Shi H, Winkler MA, Lee R, Weintraub NL.Arterioscler Thromb Vasc Biol. 2020 Sep 3:ATVBAHA120312470. doi: 10.1161/ATVBAHA.120.312470. Online ahead of print.PMID: 32878476

 

 

Nf1 heterozygous mice recapitulate the anthropometric and metabolic features of human neurofibromatosis type 1.

Tritz R, Benson T, Harris V, Hudson FZ, Mintz J, Zhang H, Kennard S, Chen W, Stepp DW, Csanyi G, Belin de Chantemèle EJ, Weintraub NL, Stansfield BK.Transl Res. 2020 Aug 8:S1931-5244(20)30197-3. doi: 10.1016/j.trsl.2020.08.001. Online ahead of print.PMID: 32781282

 

 

PKCδ stimulates macropinocytosis via activation of SSH1-cofilin pathway.

Singla B, Lin HP, Ghoshal P, Cherian-Shaw M, Csányi G.Cell Signal. 2019 Jan;53:111-121. doi: 10.1016/j.cellsig.2018.09.018. Epub 2018 Sep 24.PMID: 30261270

 

Loaded Leukosomes: A Smart Bomb to Halt Vascular Inflammation.

Csányi G, Lucas R, Annex BH.Circ Res. 2020 Jan 3;126(1):38-40. doi: 10.1161/CIRCRESAHA.119.316249. Epub 2020 Jan 2.PMID: 31895661 

 

Leptin Restores Endothelial Function via Endothelial PPARγ-Nox1-Mediated Mechanisms in a Mouse Model of Congenital Generalized Lipodystrophy.

Bruder-Nascimento T, Faulkner JL, Haigh S, Kennard S, Antonova G, Patel VS, Fulton DJR, Chen W, Belin de Chantemèle EJ.Hypertension. 2019 Dec;74(6):1399-1408. doi: 10.1161/HYPERTENSIONAHA.119.13398. Epub 2019 Oct 28.PMID: 31656096

 

Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression.

Faulkner JL, Kennard S, Huby AC, Antonova G, Lu Q, Jaffe IZ, Patel VS, Fulton DJR, Belin de Chantemèle EJ.Hypertension. 2019 Sep;74(3):678-686. doi: 10.1161/HYPERTENSIONAHA.119.12802. Epub 2019 Jul 22.PMID: 31327274 

 

The Small GTPases Rab27b Regulates Mitochondrial Fatty Acid Oxidative Metabolism of Cardiac Mesenchymal Stem Cells.

Jin Y, Shen Y, Su X, Cai J, Liu Y, Weintraub NL, Tang Y.Front Cell Dev Biol. 2020 Apr 15;8:209. doi: 10.3389/fcell.2020.00209. eCollection 2020.PMID: 32351955

 

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis.

Barman SA, Li X, Haigh S, Kondrikov D, Mahboubi K, Bordan Z, Stepp DW, Zhou J, Wang Y, Weintraub DS, Traber P, Snider W, Jonigk D, Sullivan J, Crislip GR, Butcher JT, Thompson J, Su Y, Chen F, Fulton DJR.Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L784-L797. doi: 10.1152/ajplung.00186.2018. Epub 2019 Feb 6.PMID: 30724100

 

Increased Muscle Mass Protects Against Hypertension and Renal Injury in Obesity.

Butcher JT, Mintz JD, Larion S, Qiu S, Ruan L, Fulton DJ, Stepp DW.J Am Heart Assoc. 2018 Aug 21;7(16):e009358. doi: 10.1161/JAHA.118.009358.PMID: 30369309 

 

Origins of Hypertension in Obesity: Plain Vanilla(oid) or Multiple Flavors?

Fulton DJR, Stepp DW.Circulation. 2020 Apr 21;141(16):1334-1337. doi: 10.1161/CIRCULATIONAHA.120.046027. Epub 2020 Apr 20.PMID: 32310696 

 

Role of Arginase 2 in Murine Retinopathy Associated with Western Diet-Induced Obesity.

Atawia RT, Bunch KL, Fouda AY, Lemtalsi T, Eldahshan W, Xu Z, Saul A, Elmasry K, Al-Shabrawey M, Caldwell RB, Caldwell RW.J Clin Med. 2020 Jan 22;9(2):317. doi: 10.3390/jcm9020317.PMID: 31979105

 

Dual Role of Hydrogen Peroxide As an Oxidant in Pneumococcal Pneumonia.

Mraheil MA, Toque HA, La Pietra L, Hamacher J, Phanthok T, Verin A, Gonzales J, Su Y, Fulton D, Eaton DC, Chakraborty T, Lucas R.Antioxid Redox Signal. 2020 Aug 14. doi: 10.1089/ars.2019.7964. Online ahead of print.PMID: 32283950

 

Neddylation mediates ventricular chamber maturation through repression of Hippo signaling.

Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H.Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110. doi: 10.1073/pnas.1719309115. Epub 2018 Apr 9.PMID: 29632206 

 

 

Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure.

Li J, Yue G, Ma W, Zhang A, Zou J, Cai Y, Tang X, Wang J, Liu J, Li H, Su H.Circ Heart Fail. 2018 Oct;11(10):e004917. doi: 10.1161/CIRCHEARTFAILURE.118.004917.PMID: 30354401

 

Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms.

Verin AD, Batori R, Kovacs-Kasa A, Cherian-Shaw M, Kumar S, Czikora I, Karoor V, Strassheim D, Stenmark KR, Gerasimovskaya EV.Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C183-C193. doi: 10.1152/ajpcell.00505.2019. Epub 2020 May 20.PMID: 32432925