Vascular Biology - VBIO 9020

Weekly presentation and discussion of recent journal articles that represent an important advance in the field of cardiovascular biology. Students and Postdocs are expected to lead the discussion and answer questions in relation to the paper and field in general.  Specific focus will include "hot" topics and new methodologies related to cardiovascular biology and pathology as they emerge from the literature and how such topics/techniques can be applied to one's own research. The paper discussion will enhance the presentation, problem solving, critical thinking skills of the trainee and his/her ability to provide constructive criticism to improve scientific work.


photo of Dr. Gabor Csanyi

Dr. Gabor Csanyi

photo of Dr. Vijay Ganta

Dr. Vijay Ganta

Spring 2024

JC discussions are held in CB-3803 of the Sanders R&E Bldg unless noted otherwise

Date Speaker
January 5 Zsuzsanna Bordan, PhD Candidate in Vascular Biology
David Fulton Lab
Title: “Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension”
Circulation Research. 2023;133:508–531 | DOI:10.1161/CIRCRESAHA.122.321200.
January 12
Sonia Batan, PhD, Postdoctoral Fellow
Vijay Ganta Lab
Title: “Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy”
Nat Commun 14, 4622 (2023) |
 January 19 Amr Salem, PhD, Postdoctoral Fellow
Joseph Miano Lab
Title: “Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation”
Immunity 56, 2325–2341 (2023) |
 January 26 Nestor Ishimwe, PhD, Postdoctoral Fellow
Joseph Miano Lab
Title: “Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein  S-Sulfhydration”
Circulation. 2023;147:1382–1403 | DOI: 10.1161/CIRCULATIONAHA.122.062743
 February 2 Andrew Speese, PhD Candidate in Vascular Biology
David Stepp Lab
Title: “Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells”
Genome Med. 2023 Nov 10;15(1):95 | DOI: 10.1186/s13073-023-01250-y.
 February 9 Taylor Kress, PhD Candidate in Vascular Biology
Eric Belin de Chantemele Lab
Title: “CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6”
Circulation Research. 2024;134:9–29 | DOI: 10.1161/CIRCRESAHA.123.322835
 February 16 Yoichi Ono, PhD, Postdoctoral Fellow
Eric Belin de Chantemele Lab
Title:  “Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling”
Nature Communications (2022) 13:5117 |
 February 23 Sheela Nagarkoti, PhD, Postdoctoral Fellow
Masuko Ushio-Fukai Lab
Title: “Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation”
Cell Reports 42(11):113361 | DOI:10.1016/j.celrep.2023.113361.
 March 1 Maryam Razaei-Gazik, PhD, Postdoctoral Fellow
Jie Li Lab
Title: “Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart”
Nucleic Acids Res. 2023 Jun 23;51(11):5301-5324 | doi: 10.1093/nar/gkad121.
 March 8 NO Journal Club
 March 15 Rahul Patil, PhD, Postdoctoral Fellow
Alexander Verin Lab
Title: “MicroRNA-1 protects the endothelium in acute lung injury”
JCI Insight. 2023 Sep 22;8(18):e164816 | doi: 10.1172/jci.
 March 22 Mai Yamamoto, PhD, Postdoctoral Fellow
Tohru Fukai Lab
Title: “Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization”
Neuroinflammation (2023) 20:308 |
 March 29 Ishara M.G. Menik, PhD Student
Eric Belin de Chantemele Lab
Title: “Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells”
Arterioscler Thromb Vasc Biol. 2024 Jan.44(1):238-253 |
April 5 No Journal Club
April 12 Chang Min Lee, PhD Student
Jie Li Lab
Title: “HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells”
Circulation. 2023;149:00–00 | DOI: 10.1161/CIRCULATIONAHA.123.064735
April 19 Qimei Han, PhD, Postdoctoral Fellow
Brian Annex Lab
Title: “Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence”
Circulation Research. 2023;133:842–857 | DOI: 10.1161/CIRCRESAHA.123.323084
April 26 Mohamed Nofal, PhD, Postdoctoral Fellow
Brian Annex Lab
Title: Hyperglycolysis in endothelial cells drives endothelial injury and microvascular alterations in peritoneal dialysis”
Clin. Transl. Med. 2023;13:e1498 |

May 3


Beryl Khakina, PhD Student
Eric Belin de Chantemele Lab
May 10 Beryl Khakina, PhD Student
Eric Belin de Chantemele Lab
Title: “LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of Delayed rt-PA Therapy and Improves Outcomes After Acute Ischemic Stroke"
Circulation Research. 2024;134:954–969 | DOI: 10.1161/CIRCRESAHA.123.323371
May 17 Sadikul Islam, PhD, Postdoctoral Fellow
Habo Su Lab

Past Years

Date Speaker
August 18 Beryl Khakina, PhD Student
Eric Belin de Chantemele Lab
Title: “Angiotensin II–Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats”
Hypertension. 2023;80:1258–1273. DOI: 10.1161/HYPERTENSIONAHA.123.21070
August 25 Hunter Sellers, PhD Candidate
David Fulton Lab
Title: “Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression"
Nat Methods 20, 1070–1081 (2023).
September 1 Candee Barris, PhD Candidate
Eric Belin de Chantemele Lab
Title: “Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts”
Circulation. 2022;145:513–530. DOI: 10.1161/CIRCULATIONAHA.121.054108
September 8 Zach Brown, PhD Student
David Fulton Lab
Title: SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension
Circulation. 2023;147:1606–1621. DOI: 10.1161/CIRCULATIONAHA.122.061940
September 15 Jaser Doja, PhD Candidate
Joe Miano Lab
Title: "Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta"
JCI Insight. 2023;8(17):e170845.
September 22 Md. Selim Hossain, PhD, Postdoctoral Fellow
Masuko Ushio-Fukai Lab
Title: Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway”
NPAS. 2023 Aug 15;120(33):e2303809120. doi: 10.1073/pnas.2303809120.
September 29 Steve Haigh, PhD Candidate
David Fulton Lab
Title: “Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes”
Science 381, eadh5207 (2023). DOI:10.1126/science.adh5207
 October 6 Suhib Alhusban, PhD Candidate
Brian Annex Lab
Title: “ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress”
Circulation Research. 2022;131:91–105. DOI: 10.1161/CIRCRESAHA.122.321050
 October 13 Cody Rosewater, PhD Student
David Stepp Lab
Title: Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice
Nat Commun 14, 2947 (2023).
 October 20 Ishara M.G. Menik, PhD Student
Eric Belin de Chantemele Lab
Title:“Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia”
Circulation Research. 2023;132:674–689. DOI: 10.1161/CIRCRESAHA.122.321228
 October 27 WonMo Ahn, PhD Candidate
Gabor Csanyi Lab
Title: “Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice”
Nat Commun 14, 4101 (2023).
 November 3 Josue Zambrano-Carrasco, PhD Student
Huabo Su Lab
Title: “Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1
Circulation Research. 2023;133:48–67. DOI: 10.1161/CIRCRESAHA.122.322223
 November 10 No Journal Club
 November 17 No Journal Club
 November 24 No Journal Club
 December 1 David Kim, PhD Candidate
Neal Weintraub Lab
Title: "BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility"
Nucleic Acids Res. 2023 May 22;51(9):4284-4301 / DOI:10.1093/nar/gkad120
 December 8 Mitch Shivers, PhD Student
David Fulton Lab

“ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension”journal

 December 15 Chang Min Lee, PhD Student
Jie Li Lab
Title: “Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target”
PNAS 2023;120(11): e2215732120.
 December 22 No Journal Club
 December 29 No Journal Club


Date Speaker
August 18 Hunter Sellers, PhD Candidate
Brian Annex Lab
Title: "Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway"
Theranostics 2022,12(11): 5172-5188. doi: 10.7150/thno.71585
January 13 Taylor Kress, PhD Candidate
Eric Belin de Chantemele Lab
Title: "Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis"
Circulation. 2023;147:00–00. DOI: 10.1161/CIRCULATIONAHA.122.061025
January 20 Yoichi Ono, MD, PhD, Postdoctoral Fellow
Eric Belin de Chantemele Lab
Title: "Praliciguat Promotes Ischemic Leg Reperfusion in Leptin Receptor-Deficient Mice"
Circulation Research. 2023;132:34–48. DOI: 10.1161/CIRCRESAHA.122.322033
January 27 Zach Brown, Graduate Student
David Fulton Lab
Title: "Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression
Circulation. 2023;147:00–00. DOI: 10.1161/CIRCULATIONAHA.122.058794
February 3 Maria Blahove, Graduate Student
Gabor Csanyi Lab
Title: "Granulocyte microvesicles with a high plasmin generation capacity promote clot lysis and improve outcome in septic shock"
Blood. 2022 Apr 14;139(15):2377-2391 | DOI: 10.1182/blood.2021013328
February 10 Mitch Shivers, Graduate Student
David Fulton Lab
Title: Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism”
Arterioscler Thromb Vasc Biol. 2023;43:00–00. DOI: 10.1161/ATVBAHA.122.318420
February 17 Cody Rosewater, Graduate Student
David Stepp Lab
Title: "Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis"
Nat Cardiovasc Res. Vol 1:1156–1173 /
February 24 Josue Zambrano-Carrasco, Graduate Student
Huabo Su Lab
Title: “Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts”
Developmental Cell 57, 2397–2411 /
March 3 Adeel Zaidi, PhD, Assistant Research Scientist
Ruth Caldwell Lab
Title: "HIF-1a accumulation in response to transient hypoglycemia may worsen diabetic eye disease"
Cell Reports. 42(1)111976 |
March 10 Canceled
March 17 No Journal Club  - Graduate Research Day Events (3/16-3/17)
March 24 Shikha Yadav, PhD, Postdoctoral Fellow
Masuko Ushio-Fukai Lab
Title: "Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease"
Nat Cardiovasc Res 1, 28–44 (2022) |
March 31 Karl Diaz-Sanders, Graduate Student
Jennifer Sullivan Lab
Title: “CAR T cells produced in vivo to treat cardiac injury”
Science 375, 91–96 (2022) | DOI: 10.1126/science.abm0594
April 7 No Journal Club - Spring Break
April 14 Anil Sakamuri, PhD, Postdoctoral Fellow
Ben Ogola Lab
Title: "Flavonifractorplautii Protects Against Elevated Arterial Stiffness"
Circ. Res. 2023;132:167–181. DOI: 10.1161/CIRCRESAHA.122.321975
April 21 No Journal Club 
April 28 Sheela Nagarkoti PhD, Postdoctoral Fellow
Masuko Ushio-Fukai and Tohru Fukai Labs
Title: “Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after  myocardial infarction
Sci. Adv., 9 (5), eadc9465. DOI: 10.1126/sciadv.adc9465
May 5 Anita Kovacs-Kasa, PhD, Assistant Research Scientist
Brian Annex Lab
Title: “MicroRNA‑375 repression of Kruppel‑like  factor 5 improves angiogenesis in diabetic critical limb ischemia"
is (2023) 26:107–127 |
Yusra Zaidi, PhD,
 Postdoctoral Fellow
Brian Stansfield Lab
May 19 Tongfeng Cai, Visiting Scholar
Yuqing Hou Lab
Title: “The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques”
Nature Aging | Volume 3 | January 2023 | 64–81 |
May 26 Chen Qu, PhD, Postdoctoral Fellow
Huabo Su Lab
Title: Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis”
Circ. 2023;147:00–00. DOI: 10.1161/CIRCULATIONAHA.122.061131
June 2  Chang Min Lee, Graduate Student
Jie Li Lab
Title: "The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3"
Nat. Comm. (2022) 13:7857 |
June 9 Yusra Zaidi, PhD, Postdoctoral Fellow
Brian Stansfield Lab
Title: "Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy"
Nat Comm | ( 2022) 13:6045 |

Date Speaker
August 19 Hunter Sellers, PhD Candidate
David Fulton Lab 
Title: "Oocytes maintain ROS-free mitochondrial metabolis by suppressing complex I"
Nature 607:756-761. 2022 /
August 26 Brandee Goo, MD/PhD Candidate
Neal Weintraub Lab
Title: "Extracellular Vesicle-based interorgan transport of mitochondria from energetically stressed adiposytes"
Cell Metabolism 33:1853-1868 /
September 2 Zsuzsanna Bordan, PhD Candidate
David Fulton Lab
Title: "Chitinase 3-like-1 contributes to the development of pulmonary vascular remodeling in pulmonary hypertension"
JCI Insight.2022 / 
September 9 Drew Speese, PhD Candidate
David Stepp Lab
Title: "Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity"
Nat Aging 2, 714-725.2022 /
September 16 Steve Haigh, PhD Candidate
David Fulton Lab
Title: "Dichotomous Roles of Smooth Muscle Cell-Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis"
Arterioscler Thromb Vasc Biol. 2022;42:942-956 / DOI.10.1164/ATVBAHA.122.347882
September 23 Jaser Doja, Graduate Student
Joe Miano Lab
Title: "Spatial multi-omic map of human myocardial infarction"
Nature.608,766-777(2022) /
September 30 WonMo Ahn, Graduate Student
Gabor Csanyi Lab
Title: "The Amino Acid homoarginine Inhibits Atherogenesis by Modulating T-Cell Function"
Circulation Research. 2022;131:00-00 / DOI:10.1161/CIRCRESAHA.122.321094
October 7 Candee Barris, Graduate Student
Eric Belin de Chantemele Lab
Title: "Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality"
Science 377:292-297 / DOI:10.1126/science.abn3100
October 14 David Kim, MD/PhD Candidate
Neal Weintraub Lab
Title: "Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms"
J. Exp. Med. 2021. 218(6):1-19.DOI:org/10.1084/jem.20201839
October 21 Ragheb Harb, MD, Postdoctoral Fellow
Neal Weintraub Lab
Title: "Inhibition of macrophage histone demethylas JMJD3 protects against abdominal aortic aneurysms"
J. Exp. Med.2021.218(6):1-19.DOI:org/10.1084/jem.20201839
October 28 Maria Blahove, Graduate Student
Gabor Csanyi Lab
Title: "Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation"
Circulation. 2021;143:2475–2493.DOI: 10.1161/CIRCULATIONAHA.120.052009
November 4 NO Journal Club
November 11 Zach Brown, Graduate Student
David Fulton Lab
Title: "Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species"
Cell. 2021 Sept 16;184(19):4919-4938.e22 / DOI:10.1016/j.cell.2021.08.028.
November 18 Josue Zambrano-Carrasco, Graduate Student
Huabo Su Lab
Title: "PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle"
Circulation. 2022;145:586–602.DOI:10.1161/CIRCULATIONAHA.121.056666
November 25 NO Journal Club
December 2 Cody Rosewater, Graduate Student
David Stepp Lab
Title: Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library"
Sci. Transl. Med.14(660),eabo0699 /
December 9 Mitch Shivers, Graduate Student
David Fulton Lab
Title:  “Robust genome editing in adult vascular endothelium by nanoparticle delivery of  CRISPR-Cas9 plasmid DNA”
Cell Reports 38, Jan 2, 2022 /
December 16 Karl Diaz-Sanders, Graduate Student
Jennifer Sullivan Lab
Title: "miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques"
Circ Res. 2021 April 16; 128(8):1122-1138. DOI:10.1161/CIRCRESAHA.120.317914
December 23 and 30 NO Journal Club