Primary Faculty
Investigates role of cholinergic systems in memory function, and how it is altered by diseases like schizophrenia and Alzheimer's Disease as well as toxins that are found in the environment such as organophosphate insecticides.
Scott A. Barman, PhD, FAHA
- Regents' Professor & Vice Chair for Education
706-721-6352
Investigates signal transduction mechanisms, mostly associated with Galectin-3 and Nox4 which is involved in Pulmonary Hypertension (PH).
Studies role of availability of L-arginine for NOS in the cardiovascular dysfunctions in diabetes, hypertension, obesity and other diseases involving oxidative stress and inflammation. The group investigates the involvement of altered arginase expression and activity.
Focuses on developing therapies against Alzheimer’s disease and related dementias.
Investigates neurobiological mechanisms underlying addiction and its comorbidities.
Nevin A. Lambert, PhD
- Regents' Professor & Vice Chair for Research
706-721-6336
Investigates structure and function of G-protein-coupled receptor (GPCR) signaling complexes. His work uses biophysical methods such as resonance energy transfer and confocal imaging in living cells to investigate receptor quaternary structure and receptor-G protein coupling.
Investigates the rules and mechanisms governing information transfer between neurons, which are essential processes to provide instructions for locomotion and motor coordination. Research utilizes CRISPR/Cas9 gene editing tools in tandem with optical imaging strategies to interrogate the molecular architecture underlying neuronal signal decoding logic.
Investigates molecular basis of organ function changes following injury and the influence of aging using a multidisciplinary approach. His research is currently focused on mitochondrial alterations and immune regulation following hemorrhagic shock towards identification of molecular mechanisms and therapeutic targets.
Investigates regulation of the cardiovascular system by intrinsic daily oscillations/rhythms (a circadian rhythm). Examines gene transcription factors Bmal1 and Clock as the molecular basis of these rhythmic patterns and vascular dysfunction.
Investigates the regulatory mechanisms of pulmonary circulation and lung injury and repair. The focus is on three areas: protein-protein interaction in lung endothelial signaling, calpain in hypoxic pulmonary vascular remodeling and angiogenesis, and lung injury and repair in tobacco smoke exposure.
Our studies focus on the identification and characterization of molecular targets of brain injury after intracerebral hemorrhage, a fatal stroke subtype employing both genetic and pharmacological approaches.
Uses a multilevel approach to investigate forebrain networks involved in encoding and consolidating of memories for emotional events in models of anxiety and impaired cognitive flexibility with special focus on individual differences. The lab has created an animal model of susceptibility for developing Post-Traumatic Stress Disorder.
Studies G protein-coupled receptor (GPCRs) trafficking, particularly anterograde transport of nascent receptors to the functional destinations en route from the endoplasmic reticulum and the Golgi apparatus. Also investigates the role of G protein-mediated signaling in cancer biology.
Dr Zhu’s main research is to determine the molecular mechanisms of HIV-1 infection-induced neurological disorders in HIV-1 patients with concurrent substance abuse.
Center Faculty With Primary Appointments in Pharmacology & Toxicology
Our lab focuses on macrophage biology in atherosclerosis.
Our lab focuses on oxidative stress and copper transporters in vascular metabolic disease.
Our lab focuses on the role of endothelium and reactive oxygen and nitrogen species in cardiovascular disease.
Our lab focuses on novel therapies for pulmonary edema.
Marco Orecchioni, PhD
- Immunology Center of Georgia
- Assistant Professor
706-721-0944
Our lab focuses on protein quality control in cardiac disease.