The Miano lab has developed dozens of rodent models, primarily with gene editing platforms,
to study previously challenging research questions in vascular smooth muscle cell
pathobiology. Current topics of interest include the control of smooth muscle gene
transcription in vivo, vascular smooth muscle cell-restricted gene knockouts, Myocardin
protein biology, and the ACE2/ACE2-DT gene pair in SARS-CoV-2 infection and (long) COVID-19 disease.
Research Projects
Transcriptional/post-transcriptional regulation of the SRF-Myocardin switch
Function and regulation of novel SRF-Myocardin target genes
CArG-SNP discovery and activity
LncRNA discovery and function
Development of new mouse models and correction of Mendelian traits in utero using Prime editing
Development of new rat models to interrogate the SRF-Myocardin switch under various
stress conditions (eg, exercise and disease models)
