Phone: (706) 721-8819
Fax: (706) 721-7299
Email: zbagi@augusta.edu
Office: CA-3133
Lab: CA-3132A
General Semmelweis University of Budap, Biomedical Sciences, PhD, 2004
Semmelweis University of Budap, Medicine, MD, 2000
2001-2010| Assistant Professor, New York Medical College
2010-2012 | Intermediate Research Fellow, British Heart Foundation Center of Research Excellence at University of Oxford
2011-2013 | Senior Research Fellow, Somerville College, Oxford University
2013 - 2019 | Associate Professor, Augusta University
2019 | Professor, Deparment of Physiology, Medical College of Georgia, Augusta University
Jump to: Research Interests Awards & Honors Related Links About Dr. Bagi's Research Lab
LAB PERSONNEL
Liwei Lang, PhD
Assistant Research Scientist
Marta Bagine Balogh
Research Associate
Vadym Buncha
Graduate Student
Katherine Fopiano
Graduate Student
Coronary microvascular disease in patients with diabetes mellitus and diastolic heart failure.
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Altered copper transport in oxidative stress-dependent brain endothelial barrier dysfunction associated with Alzheimer's diseaseHossain, M. S., Das, A., Rafiq, A. M., Deak, F., Bagi, Z., Outlaw, R., Sudhahar, V., Yamamoto, M., Kaplan, J. H., Fukai, M. & Fukai, T., Dec 2024, In: Vascular Pharmacology. 157, 107433.Research output: Contribution to journal › Article › peer-review |
Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in miceBuncha, V., Fopiano, K. A., Lang, L., Ilatovskaya, D. V., Verin, A. & Bagi, Z., Oct 2024, In: GeroScience. 46, 5, p. 5191-5202 12 p.Research output: Contribution to journal › Article › peer-review |
AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in miceZhou, H., Fick, K., Patel, V., Hilton, L. R., Kim, H. W., Bagi, Z., Weintraub, N. L. & Chen, W., Jul 2024, In: American Journal of Physiology - Endocrinology and Metabolism. 327, 1, p. E69-E80Research output: Contribution to journal › Article › peer-review |
Zinc-Dependent Histone Deacetylases in Lung Endothelial PathobiologyPatil, R. S., Maloney, M. E., Lucas, R., Fulton, D. J. R., Patel, V., Bagi, Z., Kovacs-Kasa, A., Kovacs, L., Su, Y. & Verin, A. D., Feb 2024, In: Biomolecules. 14, 2, 140.Research output: Contribution to journal › Review article › peer-review |
The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s diseaseTian, Y., Fopiano, K. A., Buncha, V., Lang, L., Suggs, H. A., Wang, R., Rudic, R. D., Filosa, J. A. & Bagi, Z., 2023, In: Frontiers in Molecular Neuroscience. 16, 1125932.Research output: Contribution to journal › Article › peer-review |
Microvascular contributions to white matter injury in Alzheimer’s diseaseBagi, Z., Sherman, L. S. & Back, S. A., 2023, In: Aging. 15, 16, p. 7860-7862 3 p.Research output: Contribution to journal › Editorial › peer-review |
Mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunctionBuncha, V., Fopiano, K. A., Lang, L., Williams, C., Horuzsko, A., Filosa, J. A., Kapuku, G. & Bagi, Z., Mar 2023, In: Physiological reports. 11, 6, e15643.Research output: Contribution to journal › Article › peer-review |
Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine BrainAdeniyi, P. A., Fopiano, K. A., Banine, F., Garcia, M., Gong, X., Keene, C. D., Sherman, L. S., Bagi, Z. & Back, S. A., 2022, In: ASN Neuro. 14Research output: Contribution to journal › Article › peer-review |
Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced EndotoxemiaXu, J., Wang, L., Yang, Q., Ma, Q., Zhou, Y., Cai, Y., Mao, X., Da, Q., Lu, T., Su, Y., Bagi, Z., Lucas, R., Liu, Z., Hong, M., Ouyang, K. & Jiao, K., 2021, In: Frontiers in Cardiovascular Medicine. 8, p. 745810 745810.Research output: Contribution to journal › Article › peer-review |
Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s diseaseBagi, Z., Kroenke, C. D., Fopiano, K. A., Tian, Y., Filosa, J. A., Sherman, L. S., Larson, E. B., Keene, C. D., Degener O’Brien, K., Adeniyi, P. A. & Back, S. A., Aug 2022, In: GeroScience. 44, 4, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review |
Coronary Microvascular Dysfunction and Heart Failure with Preserved Ejection Fraction-implications for Chronic Inflammatory MechanismsFopiano, K. A., Jalnapurkar, S., Davila, A. C., Arora, V. & Bagi, Z., Mar 2022, In: Current Cardiology Reviews. 18, 2, p. 6-14 9 p., e310821195986.Research output: Contribution to journal › Article › peer-review |
Role of Caveolae in the Development of Microvascular Dysfunction and Hyperglycemia in Type 2 DiabetesTian, Y., Fopiano, K. A., Patel, V. S., Feher, A. & Bagi, Z., Feb 18 2022, In: Frontiers in Physiology. 13, 825018.Research output: Contribution to journal › Article › peer-review |
GDP in Dialysis Associates with Peritoneal Vascular Remodeling in Kidney DiseaseHan, Q., Orr, Z. J., DeSouza, G. K., Bagi, Z. & Rudic, R. D., Aug 20 2021, In: Circulation research. 129, 5, p. 527-529 3 p.Research output: Contribution to journal › Review article › peer-review |
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Rudic, R. D., Filosa, J. A., Dou, H. & Bagi, Z., Feb 2022, In: GeroScience. 44, 1, p. 349-369 21 p.Research output: Contribution to journal › Article › peer-review |
Review: Circadian clocks and rhythms in the vascular treeHan, Q., Bagi, Z. & Daniel Rudic, R., Aug 2021, In: Current Opinion in Pharmacology. 59, p. 52-60 9 p.Research output: Contribution to journal › Review article › peer-review |
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidationKolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcão-Pires, I., Reusch, P. H., Linthout, S. V., Papp, Z., Van Heerebeek, L., Vecchione, C., Maier, L. S., Ciccarelli, M., Tschöpe, C., Mügge, A. & Bagi, Z. & 2 others, , Feb 1 2021, In: Cardiovascular Research. 117, 2, p. 495-507 13 p.Research output: Contribution to journal › Article › peer-review |
A Novel Subset of CD95+ Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy ObesityJohnson, C., Drummer IV, C., Shan, H., Shao, Y., Sun, Y., Lu, Y., Saaoud, F., Xu, K., Nanayakkara, G., Fang, P., Bagi, Z., Jiang, X., Choi, E. T., Wang, H. & Yang, X., Jan 7 2021, In: Frontiers in immunology. 11, 619951.Research output: Contribution to journal › Article › peer-review |
Effects of race, cardiac mass, and cardiac load on myocardial function trajectories from childhood to young adulthood: The augusta heart studyKapuku, G., Howie, M., Ghosh, S., Doshi, V., Bykhovsky, M., Ange, B., Halbert, J. D., Robinson, V., Bagi, Z., Harshfield, G. & George, V., 2021, In: Journal of the American Heart Association. 10, 3, p. 1-8 8 p., e015612.Research output: Contribution to journal › Article › peer-review |
Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac massHao, G., Halbert, J., Su, S., Bagi, Z., Robinson, V., Thayer, J., Harshfield, G. & Kapuku, G., 2021, In: Acta Cardiologica. 76, 10, p. 1117-1123 7 p.Research output: Contribution to journal › Article › peer-review |
Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic DisordersYang, Q., Ma, Q., Xu, J., Liu, Z., Zou, J., Shen, J., Zhou, Y., Da, Q., Mao, X., Lu, S., Fulton, D. J., Weintraub, N. L., Bagi, Z., Hong, M. & Huo, Y., 2020, In: Frontiers in Cell and Developmental Biology. 8, p. 611354 611354.Research output: Contribution to journal › Article › peer-review |
Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of HypertensionPresa, J. L., Saravia, F., Bagi, Z. & Filosa, J. A., Sep 25 2020, In: Frontiers in Physiology. 11, 584135.Research output: Contribution to journal › Review article › peer-review |
Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunctionDavila, A., Tian, Y., Czikora, I., S. Weissman, A., Weinand, N., Dong, G., Xu, J., Li, J., Su, H., Kapuku, G., Huo, Y. & Bagi, Z., Aug 1 2020, In: Microcirculation. 27, 6, e12624.Research output: Contribution to journal › Article › peer-review |
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistanceXu, J., Yang, Q., Zhang, X., Liu, Z., Cao, Y., Wang, L., Zhou, Y., Zeng, X., Ma, Q., Xu, Y., Wang, Y., Huang, L., Han, Z., Wang, T., Stepp, D., Bagi, Z., Wu, C., Hong, M. & Huo, Y., Aug 2019, In: Journal of Endocrinology. 242, 2, p. 159-172 14 p.Research output: Contribution to journal › Article › peer-review |
Adenosine kinase inhibition augments conducted vasodilation and prevents left ventricle diastolic dysfunction in heart failure with preserved ejection fractionDavila, A., Tian, Y., Czikora, I., Li, J., Su, H., Huo, Y., Patel, V., Robinson, V., Kapuku, G., Weintraub, N. & Bagi, Z., Aug 1 2019, In: Circulation: Heart Failure. 12, 8, e005762.Research output: Contribution to journal › Article › peer-review |
Extracellular vesicle integrins act as a nexus for platelet adhesion in cerebral microvesselsBagi, Z., Couch, Y., Broskova, Z., Perez-Balderas, F., Yeo, T., Davis, S., Fischer, R., Sibson, N. R., Davis, B. G. & Anthony, D. C., Dec 1 2019, In: Scientific reports. 9, 1, 15847.Research output: Contribution to journal › Article › peer-review |
Akt2 (protein kinase B beta) stabilizes ATP7A, a copper transporter for extracellular superoxide dismutase, in vascular smooth muscle: Novel mechanism to limit endothelial dysfunction in type 2 diabetes mellitusSudhahar, V., Okur, M. N., Bagi, Z., O'Bryan, J. P., Hay, N., Makino, A., Patel, V. S., Phillips, S. A., Stepp, D., Ushio-Fukai, M. & Fukai, T., 2018, In: Arteriosclerosis, thrombosis, and vascular biology. 38, 3, p. 529-541 13 p.Research output: Contribution to journal › Article › peer-review |
Too much TRAFfic at the crossroads of diabetes and endothelial dysfunctionBagi, Z., Jan 2018, In: American Journal of Physiology - Heart and Circulatory Physiology. 314, 1, p. H65-H67Research output: Contribution to journal › Editorial › peer-review |
Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matterBagi, Z., Brandner, D. D., Le, P., McNeal, D. W., Gong, X., Dou, H., Fulton, D. J., Beller, A., Ngyuen, T., Larson, E. B., Montine, T. J., Keene, C. D. & Back, S. A., Jan 2018, In: Annals of Neurology. 83, 1, p. 142-152 11 p.Research output: Contribution to journal › Article › peer-review |
Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In: Cardiovascular Research. 113, 13, p. 1664-1676 13 p.Research output: Contribution to journal › Article › peer-review |
Obesity-induced vascular inflammation involves elevated arginase activityYao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571Research output: Contribution to journal › Article › peer-review |
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammationXu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., Liu, Z., An, X., Flores Toque, H. A., Dong, Z., Jiang, X., Fulton, D. J., Weintraub, N. L., Li, Q., Bagi, Z., Hong, M., Boison, D., Wu, C. & Huo, Y., Dec 1 2017, In: Nature communications. 8, 1, 943.Research output: Contribution to journal › Article › peer-review |
MicroRNA-155 deficiency leads to decreased atherosclerosis, increased white adipose tissue obesity, and non-alcoholic fatty liver disease a novel mouse model of obesity paradoxVirtue, A., Johnson, C., Lopez-Pastraña, J., Shao, Y., Fu, H., Li, X., Li, Y. F., Yin, Y., Mai, J., Rizzo, V., Tordoff, M., Bagi, Z., Shan, H., Jiang, X., Wang, H. & Yang, X. F., Jan 27 2017, In: Journal of Biological Chemistry. 292, 4, p. 1267-1287 21 p.Research output: Contribution to journal › Article › peer-review |
Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesisXu, Y., Wang, Y., Yan, S., Zhou, Y., Yang, Q., Pan, Y., Zeng, X., An, X., Liu, Z., Wang, L., Xu, J., Cao, Y., Fulton, D. J., Weintraub, N. L., Bagi, Z., Hoda, M. N., Wang, X., Li, Q., Hong, M. & Jiang, X. & 4 others, , Sep 2017, In: EMBO Molecular Medicine. 9, 9, p. 1263-1278 16 p.Research output: Contribution to journal › Article › peer-review |
Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular DysfunctionDou, H., Feher, A., Davila, A. C., Romero, M. J., Patel, V. S., Kamath, V. M., Gooz, M. B., Rudic, R. D., Lucas, R., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Jun 1 2017, In: Arteriosclerosis, thrombosis, and vascular biology. 37, 6, p. 1180-1193 14 p.Research output: Contribution to journal › Article › peer-review |
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesityYiew, N. K. H., Chatterjee, T. K., Tang, Y. L., Pellenberg, R., Stansfield, B. K., Bagi, Z., Fulton, D. J., Stepp, D. W., Chen, W., Patel, V., Kamath, V. M., Litwin, S. E., Hui, D. Y., Rudich, S. M., Kim, H. W. & Weintraub, N. L., Apr 14 2017, In: Journal of Biological Chemistry. 292, 15, p. 6312-6324 13 p.Research output: Contribution to journal › Article › peer-review |
Assessing myogenic response and vasoactivity in resistance mesenteric arteries using pressure myographyJadeja, R. N., Rachakonda, V., Bagi, Z. & Khurana, S., Jul 6 2015, In: Journal of Visualized Experiments. 2015, 101, p. 1-7 7 p., e50997.Research output: Contribution to journal › Article › peer-review |
Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressureCzikora, I., Feher, A., Lucas, R., Fulton, D. J. R. & Bagi, Z., Mar 1 2015, In: American Journal of Physiology - Heart and Circulatory Physiology. 308, 5, p. H376-H385Research output: Contribution to journal › Article › peer-review |
Activation of calpain-2 by mediators in pulmonary vascular remodeling of pulmonary arterial hypertensionKovacs, L., Han, W., Rafikov, R., Bagi, Z., Offermanns, S., Saido, T. C., Black, S. M. & Su, Y., Mar 2016, In: American journal of respiratory cell and molecular biology. 54, 3, p. 384-393 10 p.Research output: Contribution to journal › Article › peer-review |
Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetesRomero Lucas, M. J., Lucas, R., Dou, H., Sridhar, S., Czikora, I., Mosieri, E. M., Rick, F. G., Block, N. L., Sridhar, S., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Feb 16 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1895-1900 6 p.Research output: Contribution to journal › Article › peer-review |
Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in MicePati, P., Fulton, D. J. R., Bagi, Z., Chen, F., Wang, Y., Kitchens, J., Cassis, L. A., Stepp, D. W. & Rudic, R. D., Mar 1 2016, In: Hypertension. 67, 3, p. 661-668 8 p.Research output: Contribution to journal › Article › peer-review |
Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperonesChen, F., Haigh, S., Yu, Y., Benson, T., Wang, Y., Li, X., Dou, H., Bagi, Z., Verin, A. D., Stepp, D. W., Csanyi, G., Chadli, A., Weintraub, N. L., Smith, S. M. E. & Fulton, D. J. R., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 793-805 13 p.Research output: Contribution to journal › Article › peer-review |
Impaired coronary collateral growth: MiR-shaken neutrophils caught in the actBagi, Z., Jun 1 2015, In: American Journal of Physiology - Heart and Circulatory Physiology. 308, 11, p. H1321-H1322Research output: Contribution to journal › Editorial › peer-review |
Erratum:Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species(Free Radical Biology and Medicine (2014) 73 (201-213) (DOI 10.1016/j.freeradbiomed.2014.11.001))Chen, F., Barman, S. A., Yu, Y., Haigh, S., Wang, Y., Black, S. M., Rafikov, R., Dou, H., Bagi, Z., Han, W., Su, Y. & Fulton, D. J., Apr 2015, In: Free Radical Biology and Medicine. 81, p. 184 1 p.Research output: Contribution to journal › Comment/debate › peer-review |
Obesity and coronary microvascular disease-implications for adipose tissue-mediated remote inflammatory responseBagi, Z., Broskova, Z. & Feher, A., Jan 1 2014, In: Current Vascular Pharmacology. 12, 3, p. 453-461 9 p.Research output: Contribution to journal › Article › peer-review |
Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: Rational design through target quantificationJefferson, A., Wijesurendra, R. S., McAteer, M. A., Digby, J. E., Douglas, G., Bannister, T., Perez-Balderas, F., Bagi, Z., Lindsay, A. C. & Choudhury, R. P., Dec 2011, In: Atherosclerosis. 219, 2, p. 579-587 9 p.Research output: Contribution to journal › Article › peer-review |
Cardiac electrophysiological effects of citalopram in guinea pig papillary muscle: Comparison with clomipraminePacher, P., Bagi, Z., Lakó-Futó, Z., Ungvári, Z., Nánási, P. P. & Kecskeméti, V., Jan 2000, In: General Pharmacology. 34, 1, p. 17-23 7 p.Research output: Contribution to journal › Article › peer-review |
Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH4Bagi, Z., Toth, E., Koller, A. & Kaley, G., Aug 2004, In: American Journal of Physiology - Heart and Circulatory Physiology. 287, 2 56-2, p. H626-H633Research output: Contribution to journal › Article › peer-review |
Levosimendan and its metabolite OR-1896 elicit KATP channel-dependent dilation in resistance arteries in vivoGödény, I., Pollesello, P., Édes, I., Papp, Z. & Bagi, Z., 2013, In: Pharmacological Reports. 65, 5, p. 1304-1310 7 p.Research output: Contribution to journal › Article › peer-review |
Activation of the poly(ADP-ribose) polymerase pathway in human heart failureMolnár, A., Tóth, A., Bagi, Z., Papp, Z., Édes, I., Vaszily, M., Galajda, Z., Papp, J. G., Varró, A., Szüts, V., Lacza, Z., Gerö, D. & Szabó, C., Jul 2006, In: Molecular Medicine. 12, 7-8, p. 143-152 10 p.Research output: Contribution to journal › Article › peer-review |
Tissue-specific regulation of microvascular diameter: Opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1Kark, T., Bagi, Z., Lizanecz, E., Pásztor, E. T., Erdei, N., Czikora, Á., Papp, Z., Édes, I., Pórszász, R. & Tóth, A., May 2008, In: Molecular pharmacology. 73, 5, p. 1405-1412 8 p.Research output: Contribution to journal › Article › peer-review |
