These faculty members are offering to be mentors to Residents looking for an opportunity
to acquire hands-on experience in research as part of their training.
This one year program is full time in a research lab with the expectation that the
Resident will present at national/international meetings, compete for research awards,
and publish one or more papers.
Our studies in the Bagi Lab focus on the investigation of the function of small blood
vessels. We want to develop a greater understanding of how coronary resistance arteries
are controlled in health and disease, and how dysfunction of arteries contribute to
organ failure. Our goal is to discover new vascular targets for therapeutic intervention
of coronary heart disease and heart failure.
Cardiovascular-renal integrative physiology and hypertension. Longstanding interest
in renal and hormonal mechanisms for chronic blood pressure and circulatory system
control in states of insulin resistance, hyperinsulinemia, and diabetes.
My research areas include clinical trials, pharmacological intervention, nutritional
supplementation, genetics/epigenetics, biomarkers and inflammation underlying obesity,
hypertension, and cardiovascular disease.
My major research interest is to gain understanding of the signaling mechanisms governing
bi-directional communication among the various cell types within the brain. In particularly,
I am interested in the communication between neurons and their surrounding glial and
vascular cells. Recent findings have demonstrated an important role for astrocytes
as intercellular bridges between the state of neuronal activity and vascular dynamics
(or neurovascular coupling). These findings have led to a number of different hypotheses
addressing the potential role astrocytes have in neurovascular coupling.
Ryan Harris, PhD - Professor - Department of Medicine
706-721-5998 / ryharris@augusta.edu / Grant Support: Clinical Research Grant, Two R01s, Vertex Pharmaceuticals IIS Grant,
AHA SFRN / CV
Cardiovascular disease remains the number one cause of death in the United States.
Under the direction of Dr. Ryan A. Harris, PhD, CEP, FACSM, the mission of the Laboratory
of Integrative Vascular and Exercise Physiology (LIVEP) is to conduct cutting-edge
research that integrates vascular and exercise physiology to understand how blood
vessels contribute to disease development. Visit us on the web at www.livep.net to learn more about what we do.
Studies in the Mattson laboratory examine the normal and pathophysiological regulation
of renal function and arterial blood pressure. A particular emphasis is placed on
the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function.
Additional studies are geared toward an understanding of the genetic basis of hypertension
and renal disease.
Our laboratory’s primary research interests lie in the physiological pathways involved
in the regulation of kidney function and how disruptions in these pathways can lead
to disease. Recently our laboratory has also become interested in the mechanisms through
which splenic anti-inflammatory pathways regulate the innate immune response.
My research laboratory is interested in understanding how the molecular mechanisms
that control circadian rhythms (circadian clocks) act on the cardiovascular system
to influence artery function and disease. We are particularly interested in defining
the particular role of endothelial cells that make up the blood vessel, and we are
now endeavoring on some new ground for us in neuroscience with the support of the
National Institute of Aging. We are seeking to determine how and if we can observe
interactions between blood vessel disease, clocks, and the brain during aging and
Alzheimer's disease using mouse models.
706-721-9796 / jensullivan@augusta.edu / Grant Support: AHA Grant In Aid, Project Leader P01, R01 / CV
The overall goal of my laboratory is to better understand the molecular mechanisms
that regulate blood pressure in males and females under both physiological and pathophysiological
conditions, including hypertension. Traditionally, it has been assumed that blood
pressure control and the basis of hypertension is the same in males and females; just
the magnitude of the response differs. However, based on the vast number of differences
that have been identified in cardiovascular physiology, pathophysiology, and pharmacology
between the sexes, there is growing evidence to suggest that the pathways by which
males and females develop cardiovascular and renal diseases may be distinct. Ongoing
studies are focused on 3 pathways involved in blood pressure control and cardiovascular
function: the renin angiotensin system (RAS), the nitric oxide (NO) pathway, and inflammation.
I have worked in the field of cytochrome P450 (CYP)-derived eicosanoids in cardiovascular
diseases, renal diseases, and diabetes for more than 20 years. Throughout these years
we have identified new compounds and pathways and elucidated their biological activities
and their therapeutically potential for treatment of cardiovascular and diabetes-associated
disorders.
Cardiovascular-renal integrative physiology and hypertension. Longstanding interest
in renal and hormonal mechanisms for chronic blood pressure and circulatory system
control in states of insulin resistance, hyperinsulinemia, and diabetes.
Obesity and its associated health comorbidities are a worldwide epidemic with serious
economic and health burden on society. The long-term research interest in the lab
is to understand the regulation of white, beige and brown adipose tissue development
and energy homeostasis, and use it to develop potential therapeutic approaches for
obesity and related metabolic diseases.
Ryan Harris, PhD - Professor - Department of Medicine
706-721-5998 / ryharris@augusta.edu / Grant Support: Clinical Research Grant, Two R01s, Vertex Pharmaceuticals IIS Grant,
AHA SFRN / CV
Cardiovascular disease remains the number one cause of death in the United States.
Under the direction of Dr. Ryan A. Harris, PhD, CEP, FACSM, the mission of the Laboratory
of Integrative Vascular and Exercise Physiology (LIVEP) is to conduct cutting-edge
research that integrates vascular and exercise physiology to understand how blood
vessels contribute to disease development. Visit us on the web at www.livep.net to learn more about what we do.
I have worked in the field of cytochrome P450 (CYP)-derived eicosanoids in cardiovascular
diseases, renal diseases, and diabetes for more than 20 years. Throughout these years
we have identified new compounds and pathways and elucidated their biological activities
and their therapeutically potential for treatment of cardiovascular and diabetes-associated
disorders.
My research interests lie in understanding the mechanisms by which hormones, growth
factors, cytokines and other signaling molecules instruct cells to respond appropriately
to perform their functions. Our current project is investigating the regulation of
keratinocyte growth and differentiation and a second defining the signaling mechanisms
regulating aldosterone secretion from the adrenal gland. In the first project in skin,
we are defining the role of the signaling enzymes phospholipase D (PLD) in promoting
epidermal keratinocyte differentiation and protein kinase D (PKD) in supporting keratinocyte
proliferation and survival.
Cardiovascular-renal integrative physiology and hypertension. Longstanding interest
in renal and hormonal mechanisms for chronic blood pressure and circulatory system
control in states of insulin resistance, hyperinsulinemia, and diabetes.
My research focuses on factors that influence the control of food intake, body weight
and body composition. We have an emphasis on the role of leptin, a hormone that is
secreted by adipose tissue and acts to suppress food intake as well as modify peripheral
metabolism and insulin sensitivity. Currently, we are examining how leptin responses
in different areas of the brain are integrated to reduce meal size, energy intake
and body fat mass.
Studies in the Mattson laboratory examine the normal and pathophysiological regulation
of renal function and arterial blood pressure. A particular emphasis is placed on
the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function.
Additional studies are geared toward an understanding of the genetic basis of hypertension
and renal disease.
The overall goal of my laboratory is to better understand the molecular mechanisms
that regulate blood pressure in males and females under both physiological and pathophysiological
conditions, including hypertension. Traditionally, it has been assumed that blood
pressure control and the basis of hypertension is the same in males and females; just
the magnitude of the response differs. However, based on the vast number of differences
that have been identified in cardiovascular physiology, pathophysiology, and pharmacology
between the sexes, there is growing evidence to suggest that the pathways by which
males and females develop cardiovascular and renal diseases may be distinct. Ongoing
studies are focused on 3 pathways involved in blood pressure control and cardiovascular
function: the renin angiotensin system (RAS), the nitric oxide (NO) pathway, and inflammation.
Cardiovascular-renal integrative physiology and hypertension. Longstanding interest
in renal and hormonal mechanisms for chronic blood pressure and circulatory system
control in states of insulin resistance, hyperinsulinemia, and diabetes.
Our research is focused on the cellular and molecular mechanisms governing water and
electrolyte handling in the kidney. The laboratory pursues a few lines of inquiry:
we study how disrupted calcium homeostasis in renal epithelial cells is associated
with polycystic kidney disease (PKD) and nephrogenic diabetes insipidus (NDI), investigate
sex-specific mechanisms governing final regulation of sodium reabsorption in the kidney,
critical for the chronic blood pressure control.
Studies in the Mattson laboratory examine the normal and pathophysiological regulation
of renal function and arterial blood pressure. A particular emphasis is placed on
the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function.
Additional studies are geared toward an understanding of the genetic basis of hypertension
and renal disease.
Our laboratory’s primary research interests lie in the physiological pathways involved
in the regulation of kidney function and how disruptions in these pathways can lead
to disease. Recently our laboratory has also become interested in the mechanisms through
which splenic anti-inflammatory pathways regulate the innate immune response.
The overall goal of my laboratory is to better understand the molecular mechanisms
that regulate blood pressure in males and females under both physiological and pathophysiological
conditions, including hypertension. Traditionally, it has been assumed that blood
pressure control and the basis of hypertension is the same in males and females; just
the magnitude of the response differs. However, based on the vast number of differences
that have been identified in cardiovascular physiology, pathophysiology, and pharmacology
between the sexes, there is growing evidence to suggest that the pathways by which
males and females develop cardiovascular and renal diseases may be distinct. Ongoing
studies are focused on 3 pathways involved in blood pressure control and cardiovascular
function: the renin angiotensin system (RAS), the nitric oxide (NO) pathway, and inflammation.
My major research interest is to gain understanding of the signaling mechanisms governing
bi-directional communication among the various cell types within the brain. In particularly,
I am interested in the communication between neurons and their surrounding glial and
vascular cells. Recent findings have demonstrated an important role for astrocytes
as intercellular bridges between the state of neuronal activity and vascular dynamics
(or neurovascular coupling). These findings have led to a number of different hypotheses
addressing the potential role astrocytes have in neurovascular coupling.
My lab’s research focuses on questions of neurovascular coupling and visual processing.
Our neurovascular coupling works seeks to determine how neural activity in the cortex
drives the hemodynamic responses (functional hyperemia) and, in turn, how neurons
depend on the increased blood flow to active regions.
My research focuses on factors that influence the control of food intake, body weight
and body composition. We have an emphasis on the role of leptin, a hormone that is
secreted by adipose tissue and acts to suppress food intake as well as modify peripheral
metabolism and insulin sensitivity. Currently, we are examining how leptin responses
in different areas of the brain are integrated to reduce meal size, energy intake
and body fat mass.
My research areas include clinical trials, pharmacological intervention, nutritional
supplementation, genetics/epigenetics, biomarkers and inflammation underlying obesity,
hypertension, and cardiovascular disease.
Obesity and its associated health comorbidities are a worldwide epidemic with serious
economic and health burden on society. The long-term research interest in the lab
is to understand the regulation of white, beige and brown adipose tissue development
and energy homeostasis, and use it to develop potential therapeutic approaches for
obesity and related metabolic diseases.
My research focuses on factors that influence the control of food intake, body weight
and body composition. We have an emphasis on the role of leptin, a hormone that is
secreted by adipose tissue and acts to suppress food intake as well as modify peripheral
metabolism and insulin sensitivity. Currently, we are examining how leptin responses
in different areas of the brain are integrated to reduce meal size, energy intake
and body fat mass.
My research interests lie in understanding the mechanisms by which hormones, growth
factors, cytokines and other signaling molecules instruct cells to respond appropriately
to perform their functions. Our current project is investigating the regulation of
keratinocyte growth and differentiation and a second defining the signaling mechanisms
regulating aldosterone secretion from the adrenal gland. In the first project in skin,
we are defining the role of the signaling enzymes phospholipase D (PLD) in promoting
epidermal keratinocyte differentiation and protein kinase D (PKD) in supporting keratinocyte
proliferation and survival.
