Emerging Scientist Award 2019, Augusta University Research Institute, Augusta University
 Sangeetha Sukumari-Ramesh, PhD
706-446-3645 |
Carl Sanders Research & Education Building, CB 3618 Members of the Lab |
Spontaneous intracerebral hemorrhage (ICH) is a stroke subtype associated with high morbidity and mortality. Around 50% of ICH patients die within the first month, and fewer than 20% of survivors regain functional independence. Moreover, the incidence of ICH is expected to grow over the next decades due to population aging and changes in racial demographics. Despite the relatively high incidence rate, there is no effective treatment for ICH, and the efficacy of neurosurgical intervention after ICH remains largely controversial. Lack of effective treatment options, at least in part, reflects on the poorly defined pathophysiology of the detrimental events underlying brain injury after ICH. The long-term goal of my laboratory is to determine the molecular and cellular mechanisms of ICH-induced brain injury and identify novel molecular targets for therapeutic intervention.
07/2019 MBA Augusta University
12/2009 Postdoctoral training Augusta University
02/2006 PhD Biochemistry Sree Chitra Tirunal Institute for Medical Sciences &Technology, India
07/1999 MS Biochemistry Kerala University, India
04/1997 B.S. Chemistry Kerala University, India
07/2021- Present Associate Professor, Department of Pharmacology and Toxicology, Medical College of Georgia
Editor, Special Issue, "Intracerebral Hemorrhage: Advances in Preclinical Studies”, Biomolecules.
American Heart Association
Veteran Affairs-Merit Review Panel
Emerging Scientist Award 2019, Augusta University Research Institute, Augusta University
Dasari R, Zhi W, Bonsack F, Sangeetha Sukumari-Ramesh. A Combined Proteomics and Bioinformatics Approach Reveals Novel Signaling Pathways and Molecular Targets After Intracerebral Hemorrhage. J Mol Neurosci. 2020 Aug;70(8):1186-1197.
Bonsack F and Sukumari-Ramesh S. Differential cellular expression of Galectin-1 and Galectin-3 after Intracerebral Hemorrhage. Front Cell Neurosci. 2019 May 14;13:157
Bonsack F, Foss C, Arbab A, Alleyne CH Jr, Pomper MG, Sukumari-Ramesh S*. [125 I] IodoDPA-713 binding to 18kDa translocator protein (TSPO) in a mouse model of intracerebral hemorrhage: Implications for neuroimaging. Front. Neurosci, 2018 Feb 22;12:66.
Bonsack F, Alleyne CH Jr, Sukumari-Ramesh S. Resveratrol attenuates neurodegeneration and improves neurological outcomes after intracerebral hemorrhage in mice. Front Cell Neurosci. 2017 Aug 8; 11:228.
Bonsack F, Alleyne CH Jr, Sukumari-Ramesh S. Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation? Journal of Neuroinflammation 2016, Jun 17;13(1):151.
Sukumari-Ramesh S*, Alleyne CH Jr, Dhandapani KM.The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Confers Acute Neuroprotection After Intracerebral Hemorrhage in Mice. Translational Stroke Research. 2016 Apr; 7(2):141-8. *both first and corresponding author
Sukumari-Ramesh S * and Alleyne CH Jr. Post injury administration of tert-butylhydroquinone attenuates acute neurological injury after Intracerebral hemorrhage in mice. Journal of Molecular Neuroscience, 2016, Apr;58(4):525-31. *both first and corresponding author