Yun Lei
Assistant Professor
Academic Appointment(s)
Medical College of Georgia
Department of Neuroscience and Regenerative Medicine
Administration
Department of The Graduate School
- ylei@augusta.edu
- (706) 446-3521
- CA2012
Education
-
DSC, Pharmacology
Chinese Academy of Sciences, 2015
-
BS, Bioengineering and Biomedical
Harbin Institute Of Technology, 2010
Courses Taught Most Recent Academic Year
Scholarship
Selected Recent Publications
- Chronic social isolation-unpredictable stress induces early-onset cognitive deficits and exacerbates Aβ accumulation in the 5xFAD mouse model of Alzheimer's disease., 2025
Journal Article, Academic Journal
- Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer’s disease-related phenotypes, 2025
Other
- Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice., 2024
Journal Article, Academic Journal
- Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology., 2024
Journal Article, Academic Journal
- Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat-fed mice., 2023
Journal Article, Academic Journal
Research Interests
My lab studies how chronic social isolation-unpredictable stress (SIUS) accelerates aging and contributes to the onset and progression of Alzheimer’s disease (AD). We are particularly interested in how chronic stress induces persistent changes in epigenetic regulation, such as histone acetylation and methylation, in specific neuronal populations within brain regions affected in the early stages of AD, and how these molecular alternations increase cellular susceptibility to degeneration, leading to cognitive impairment and the exacerbation of amyloid-β and tau pathology.
