Sangeetha Sukumari Ramesh

Scholarship

Selected Recent Publications

• Dysregulation of Serum MicroRNA after Intracerebral Hemorrhage in Aged Mice , 2023
  Journal Article, Academic Journal
• Intracerebral Hemorrhage: The Effects of Aging on Brain Injury., 2022
  Journal Article, Academic Journal
• High glucose removes natural anti-α-galactoside and anti-β-glucoside antibody immune complexes adhering to surface O-glycoproteins of normal platelets and enhances platelet aggregation., 2022
  Journal Article, Academic Journal
• Dysregulation of microRNA and Intracerebral Hemorrhage: Roles in Neuroinflammation., 2021
  Journal Article, Academic Journal
• Entinostat improves acute neurological outcomes and attenuates hematoma volume after Intracerebral Hemorrhage., 2021
  Journal Article, Academic Journal

Research Interests

Spontaneous intracerebral hemorrhage (ICH) is a stroke subtype associated with high morbidity and mortality. Around 50% of ICH patients die within the first month, and fewer than 20% of survivors regain functional independence. Moreover, the incidence of ICH is expected to grow over the next decades due to population aging and changes in racial demographics. Despite the relatively high incidence rate, there is no effective treatment for ICH, and the efficacy of neurosurgical intervention after ICH remains largely controversial. Lack of effective treatment options, at least in part, reflects on the poorly defined pathophysiology of the detrimental events underlying brain injury after ICH. The long-term goal of my laboratory is to determine the molecular and cellular mechanisms of ICH-induced brain injury and identify novel molecular targets for therapeutic intervention.