Dongwen Lyu
Assistant Professor
Dongwen Lyu
Assistant Professor
Academic Appointment(s)
Medical College of Georgia
Department of Cellular Biology and Anatomy
Medical College of Georgia
Department of Georgia Cancer Center
Administration
Department of The Graduate School
- DLYU@augusta.edu
- (706) 721-8268
- 1410 Laney-Walker Blvd, CN-3130, Augusta, GA 30912
- Personal Website
Education
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Ph.D., Genetics, General Capital Normal University, 2014
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MS, Genetics, General Capital Normal University, 2011
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BS, Biotechnology Minzu University, 2008
Courses Taught Most Recent Academic Year
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MOIM 9210
Invest of a Problem
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MOIM 9040
MOIM Journal Club
Teaching Interests
I am dedicated to teaching molecular biology and drug discovery with an emphasis on translational innovation.
Scholarship
Selected Recent Publications
- Development of polyHis-targeting PROTAC degraders, 2026
Journal Article, Academic Journal - An unbiased proteomic platform for activity-based arginylation profiling. , 2025
Journal Article, Academic Journal - Discovery of BCL-xL and BCL-w dual degrader: exploration of a new linker tethering position of ABT-263, 2025
Journal Article, Academic Journal - Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader, 2025
Journal Article, Academic Journal - Single-Assay characterization of Ternary Complex assembly and activity in targeted protein degradation, 2025
Journal Article, Academic Journal
Research Interests
My research focuses on targeted protein degradation and chemical biology approaches to modulate disease-associated proteins in cancer and aging. We develop innovative small-molecule degraders—including PROTACs, molecular glues, and next-generation platforms—and dissect mechanisms regulating protein folding, arginylation, alternative splicing, and protein quality control.
Department Service
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GCC Research Faculty Recruitment Committee 2025 - Present
Role: Committee Member
College Service
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11/15/25 IGP Review 2025 - 2026
Role: Committee Member
Professional Service
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NIH Director's Pioneer 2025 - Present
Role: Committee Member
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NIH Study Section 2025 - Present
Role: Committee Member
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NIH Study Section 2025 - Present
Role: Committee Member
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Angew. Chem. Int. Ed 2024 - Present
Role: Reviewer
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Drug Discovery Today 2024 - Present
Role: Reviewer