Darren Browning
Professor
Academic Appointment(s)
Medical College of Georgia
Department of Biochemistry and Molecular Biology
Administration
Department of The Graduate School
Bio
Educated at University of Toronto in cellular and developmental biology, post-doc in immunology at The Scripps Research Institute (La Jolla, CA). Research Faculty in University of Illinois at Chicago. Assistant professor at the Medical College of Georgia, and currently tenured full Professor at Augusta University.
Education
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Ph.D., Cell/Cellular Biology and Histology
University of Toronto, 1995
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MS, Biology/Biological Sciences, General
University of Toronto, 1990
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BS, Cell/Cellular Biology and Histology
University of Toronto, 1988
Awards & Honors
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Best of Cancer Prevention Research
American Association for Cancer Research, 2019
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Distinguished Teacher Award
The Graduate School, 2017
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Outstanding Service Award
The Graduate School, 2017
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Caught in the act of Leadership and Collegiality
AU office of Faculty Development and Teaching Excellence, 2014
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Distinguished Service Award
The Graduate School, Augusta University, 2011
Courses Taught Most Recent Academic Year
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BIOM 8021
Biochem & Gene Regulation
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MEDI 6120
Foundations of Medicine
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BIOM 8022
Molecular Cell Biology
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MEDI 6130
Musculoskeletal/Skin
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MEDI 6220
Cardiopulmonary/Heme
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BCMB 8201
Cur Topics & Tech in MB
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MEDI 6240
GI/GU/Endocrine
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MEDI 5005
Integrative Science
Teaching Interests
Medical student lectures: Signal transduction, carbohydrate structure and metabolism (glycolysis, gluconeogenesis, glycogen metabolism), heme synthesis and associated pathologies. Graduate school lectures: Carbohydrate metabolism, cyclic-nucleotide signaling, scientific communication, molecular cloning, intestinal aging.
Scholarship
Selected Recent Publications
- A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice., 2023
Journal Article, Academic Journal
- Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced BimEL dependent apoptosis in ER(+) breast cancer cells., 2023
Journal Article, Professional Journal
- Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium, 2022
Journal Article, Professional Journal
- Inhibition of colon cancer cell growth by phosphodiesterase inhibitors is independent of cGMP signaling, 2022
Journal Article, Professional Journal
- The Campylobacter jejuni Response Regulator and Cyclic-Di-GMP Binding CbrR Is a Novel Regulator of Flagellar Motility., 2021
Journal Article, Academic Journal
Research Interests
Expertise in cGMP signaling in the intestinal epithelium, with a major focus on PKG2/cGK2. Activation of intestinal cGMP/PKG2 using phosphodiesterase inhibitors (PDEi), and development of non-systemic PDEi as drug candidates. Gastrointestinal disorders, colorectal cancer, inflammatory bowel disease, irritable bowel syndrome, inflammation, epithelial biology. Signaling by cGMP, guanylyl cyclases, cGMP-dependent protein kinases.
College Service
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Three Minute Thesis Competition
2016 - Present
Role: Committee Chair
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Graduate Faculty Appointment subcommittee of the Graduate Council
2016 - Present
Role: Committee Member
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Graduate Council
2014 - Present
Role: Committee Member
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MD-PhD Admissions Committee
2013 - Present
Role: Committee Member
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Recruitment and Acceptance Committee
2006 - Present
Role: Committee Member
Professional Service
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United States Department of Veterans Affairs
2019 - 2019
Role: Reviewer, Ad Hoc Reviewer
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United States Department of Veterans Affairs
2019 - 2019
Role: Reviewer, Ad Hoc Reviewer
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AACR/Undergraduate Student Poster Competition/Judge
2019 - 2019
Role: Reviewer
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United States Department of Veterans Affairs
2018 - 2018
Role: Reviewer, Ad Hoc Reviewer
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United States Department of Veterans Affairs
2018 - 2018
Role: Committee Chair
Public Service
