Medical College of Georgia
Department of Physiology
My research program aims to understand molecular mechanisms regulating cardiovascular and renal physiology and disease. I enjoy working as part of multidisciplinary teams and mentoring students and early career researchers.
Courses spanning disciplines of anatomy, physiology, cell biology, molecular biology, genetics/genomics and graduate-level research skills.
Research mentorship for trainees ranging from undergraduate students to early career faculty.
My research is broadly focused on understanding how alterations in microRNAs and protein coding gene expression influence cardiovascular and renal physiology and pathology. My laboratory takes an integrative physiology approach to research, recognizing the interconnectedness of molecular pathways and organ systems in physiology and pathophysiology. Major focus areas of research include chronic kidney disease (CKD) and metabolic changes in CKD, the impact of CKD on pediatric growth and physiology, cardiorenal syndrome, hypertension, cardiovascular disease. polycystic kidney disease and cardio-oncology.
Frequently utilized techniques in our laboratory include: echocardiography, left ventricle pressure-volume relationship analysis, chronic and acute blood pressure recordings, sodium handling/GFR assessment, cell culture models , in vitro and in vivo miRNA/mRNA suppression, immunohistochemistry, in situ hybridization, immuno/affinity purification, western blot analysis, ELISA, proteomic/metabolomic analysis, miRNA and mRNA next generation sequencing and qRT-PCR.
