Phon
e: 706-721-3141
Email: dkrzywanski@augusta.edu
Office: CA 3365
2007-2011 Post-Doc University of Alabama at Birmingham, Birmingham, AL (Scott W. Ballinger,
Ph.D.)
2000-2006 Ph.D. Redox Biology University of Alabama at Birmingham, Birmingham, AL (Edward
M. Postlethwait, Ph.D.)
1995-1999 B.S. Biology Millersville University, Millersville, PA
1991-1995 High School Phoenixville Area High School, Phoenixville, PA
2010 Travel Award for 17th Annual Meeting of SFRBM from the Center for Free Radical Biology
(CFRB), University of Alabama at Birmingham
2010 1st Place, Postdoctoral Research Day, University of Alabama at Birmingham
2008 3rd Place, Postdoctoral Research Day, University of Alabama at Birmingham
2007 Young Investigator Award, 14th Annual Meeting of SFRBM
2006 Young Investigator Award, 14th Gordon Research Conference on Oxygen Radicals in Biology
2005 1st Place, Graduate Student Research Day, University of Alabama at Birmingham
2004 Young Investigator Award, 11th Annual Meeting of SFRBM
2004 Travel Award for 11th Annual Meeting of SFRBM from the Center for Free Radical Biology
(CFRB), University of Alabama at Birmingham
2010 Present American Heart Association (AHA)
2002 Present Society for Free Radical Biology and Medicine (SFRBM)
1. Rao, KNS., Gautier, N.M., Cockerham, E., Orr, A.W., Krzywanski, D.M. Nicotinamide
nucleotide transhydrogenase (NNT) regulates adhesion molecule expression and vascular
inflammation in early atherogenesis. Free Radical Biology and Medicine 2021; (Submitted)
2. Shackelford RE, Rao KNS, Chen J, Pardue S, Xiao AY, Kevil CG, and Krzywanski DM.
Elevated cystathionine β-synthase (CBS) expression and hydrogen sulfide production
contributes to mitochondrial dysfunction and oxidative DNA damage in Down syndrome.
Redox Biology 2021; (Submitted).
3. Schilke RM, Blackburn CMR, Rao KNS, Krzywanski DM, Finck BN, and Woolard MD. Lipin-1
regulates lipid catabolism in pro-resolving macrophages. Immunohorizons. 2020 Oct
19;4(10):659-669.
4. Rao, KNS., Shen, X., Pardue, S., Krzywanski, D.M. Nicotinamide Nucleotide Transhydrogenase
(NNT) is a critical regulator of mitochondrial ROS and endothelial dysfunction in
response to angiotensin II. Redox Biology. 2020 Sep;36:101650. doi: 10.1016/j.redox.2020.101650.
Epub 2020 Jul 23.
5. Chen PY, Wu CYC, Clemons GA, Citadin CT, Couto e Silva A, Possoit HE, Azizbayeva
R, Forren NE, Liu CH, Rao KNS, Krzywanski DM, Lee RHC, Neumann JT, Lin HW. Stearic
acid methyl ester affords neuroprotection and improves functional outcomes after cardiac
arrest. Prostaglandins Leukot Essent Fatty Acids. 2020; (Accepted)
6. Vozenilek AE, Vetkoetter M, Green JM, Shen X, Traylor JG, Klein RL, Orr AW, Woolard
MD, Krzywanski DM. Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J
Mice Exacerbates Experimental Atherosclerosis. J Vasc Res. 2018 Feb 16;55(2):98-110.
7. Leskov, I., Neville, A., Shen, X., Pardue, S., Kevil, C.G., Granger, D.N., Krzywanski,
D.M. Nicotinamide nucleotide transhydrogenase activity impacts mitochondrial redox
balance and the development of hypertension in mice. J Am Soc Hypertens. 2017 Feb;11(2):110-121.
8. Krzywanski, D.M., Ballinger, C.A., Adgent, M.A., Squadrito, G.L., Lancaster Jr.,
J.R., Postlethwait, E.M. Nitrogen dioxide induced protein oxidation and nitration:
A critical role for antioxidants and oxidative stress in the induction of epithelial
airway responses. (In Preparation)
9. Krzywanski, D.M., Westbrook, D.G., Moellering, D.R., Snary, K.D., Lipsey, C., Schurr,
T.G., Vita, J., Dell’Italia, L., Ballinger, S.W. Endothelial Cell Bioenergetics and
Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal
Ancestry. Circ Cardiovasc Genet. 2016 Feb;9(1):26-36.
10. Adgent, M.A., Squadrito, G.L., Ballinger, C.A., Krzywanski, D.M., Lancaster Jr.,
J.R., Postlethwait, E.M. Desferrioxamine inhibits membrane nitration by nitrogen dioxide
via facile protein tyrosyl radical reduction. Free Radic Biol Med. 2012 Aug 15;53(4):951-61.
11. Krzywanski, D.M., Moellering, D.R., Fetterman, J.L., Snary, K. D., Sammy, M.,
Ballinger, S.W. The mitochondrial paradigm for cardiovascular disease susceptibility
and cellular function: A complementary concept to Mendelian genetics. Lab Invest.
2011 Aug;91(8):1122-35.
12. Liu R.M., Choi J., Wu J.H., Gaston Pravia K.A., Lewis K.M., Brand J.D., Mochel
N.S., Krzywanski D.M., Lambeth J.D., Hagood J.S., Forman H.J., Thannickal V.J., Postlethwait
E.M. Oxidative modification of nuclear mitogen-activated protein kinase phosphatase
1 is involved in transforming growth factor beta1-induced expression of plasminogen
activator inhibitor 1 in fibroblasts. J Biol Chem. 2010 May 21; 285(21): 16239-47
13. Chuang, G., Yang, Z., Westbrook, D.G., Pompilius, M., Ballinger, C.A., White,
C.R., Krzywanski, D.M., Postlethwait, E.M., Ballinger, S.W. Pulmonary ozone exposure
induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol
Lung Cell Mol Physiol. 2009 Aug; 297(2):L209-16)
14. Krzywanski, D.M., Dickinson, D.A., Iles, K.E., Wigley, A.F., Franklin, C.C., Liu,
R.M., Kavanagh, T.J., Forman, H.J. Variable regulation of glutamate cysteine ligase
subunit proteins affects glutathione biosynthesis in response to oxidative stress.
Arch Biochem Biophys. 2004 Mar 1;423(1):116-25
15. Dickinson, D.A., Iles, K.E., Watanabe, N., Iwamoto, T., Zhang, H., Krzywanski,
D.M., Forman, H.J. 4-hydroxynonenal induces glutamate cysteine ligase through JNK
in HBE1 cells. Free Rad Biol Med. 2002 Oct 1;33(7):974
16. Watanabe, N., Dickinson, D.A., Krzywanski, D.M., Iles, K.E., Zhang, H., Venglarik,
C.J., Forman, H.J. A549 subclones demonstrate heterogeneity in toxicological sensitivity
and antioxidant profile. Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L726-36
17. Nagy, T.R., Krzywanski, D., Li, J., Meleth, S., Desmond, R. Effect of group vs.
single housing on phenotypic variance in C57BL/6J mice. Obes Res. 2002 May;10(5):412-5
