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Medical College of GeorgiaNeurosurgery
Neurosurgery
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  • Publications

Neurosurgery Research and Publications

Our research program aims to identify prevention measures and effective treatments for patients with neurological disorders. Our research is divided into various subspecialties, such as Cerebral Hemorrhage, Movement Disorders, Neuroprotection & Inflammation, Epilepsy, Gamma Knife Radiosurgery, Neuro-Oncology, Vascular Malformations, Degenerative Spine Disorders, Pediatric conditions and Traumatic Brain Injury (TBI). A strong collaboration between Basic Neuroscientists and Clinical Neurosurgeons is critical to the success of our mission.

Patients with specific neurosurgical conditions, who meet study-specific criteria, are invited to participate in our clinical research studies. Our clinical research activities are coordinated by a dedicated team of trained research coordinators, advanced practice providers, nurses, and therapists. Our research faculty have subspecialty training that includes research methodology, and all research is conducted under the oversight of Central and Local Institutional Review Boards. Our research funding is derived from a combination of medical industry sponsors and the National Institute of Health.

We offer a wide variety of research opportunities with our largest research projects reaching an international level and including dozens of qualified medical centers. In addition to large, multicenter clinical research, we also conduct many smaller scale investigations that involve our medical students, neurology and neurosurgery trainees.

 

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These smaller local projects introduce future physicians to research methodology as well as the essential elements of the ethical and scientific standards associated with Good Clinical Practice in human research. The findings from our local research are presented at regional and national scientific meetings.

As a research unit, we strive to make scientific discoveries to improve the healthcare of patients with acute and chronic neurological conditions.

Current Research Topics

Faculty

Hyunwoo Do, MD

Endoscopic and Minimal invasive Spine Surgery, Spinal cord injuryHyunwoo Do, MD

Fernando L. Vale, MD

Neurosurgery, Epilepsy Surgery, Deep Brain Stimulation, Low-grade gliomas

Fernando L. Vale, MD

M. Salman Ali, MD

Skull Base, Pituitary Surgery

M. Salman Ali, MD

Scott Y. Rahimi, MD

Neuroendovascular, Stroke Scott Y. Rahimi, MD

Samuel D. Macomson, MD

Hydrocephalus, Peripheral Nerve SurgerySamuel D. Macomson, MD

Khoi Nguyen, MD

Pediatric NeurosurgeryKhoi Nguyen, MD

Alexander Post, MD

Spine Surgery, Pediatric neurosurgery, Minimal access spine surgeryAlexander Post, MD

John R. Vender, MD

Gamma Knife, Surgical Pain Management John R. Vender, MD

Research Labs

Krishnan Dhandapani, PhD

Traumatic Brain Injury, Hemorrhagic Stroke, NeuroinflammationKrishnan Dhandapani, PhD

Dave Blake, PhD

Neurophysiology, Behavior, Sensory Systems, Deep Brain Stimulation

Dave Blake, PhD

Molly Braun, PhD

Glymphatic System, Neuroimmunology, Traumatic Brain Injury, Neurodegeneration, Alzheimer's Disease

Molly Braun, PhD

Kumar Vaibhav, PhD

Cannabinoid, Neuroimmunology, Senescence, Brain Injury, ErythropoiesisKumar Vaibhav, PhD

Darrell W. Brann, PhD

Neuroscience, Endocrinology, NeuroendocrinologyDarrell W. Brann, PhD

Yujiao Lu, PhD

NeuroscienceYujiao Lu, PhD

Julia V. Fomitcheva, PhD

Neuroscience

Shannon Derthick, MSc

Medical Illustration, Medical Education, Patient Education, Healthcare VisualizationShannon Derthick, MSc

Residents

William 'Luke', Ledford, MD

PGY-1

William 'Luke', Ledford, MD

Christopher Carr, MD, MPH

PGY-5

Christopher Carr, MD, MPH

Luca Debs, MD

PGY-7

Luca Debs, MD

Recent Publications

Neurosurgery Research Publications

Publication
​

Neuroinflammatory and functional outcomes after TBI are sex-dependent: Lessons from estrous-phase stratified female mice

Royal, T., Ahluwalia, P., Gulhane, M., Salles, E. L., Gaur, P., Ahluwalia, M., Randhawa, T., Sunil, S., Budim, S., Akter, K., Khan, M. B., Ghosh, S., Baban, B., Hess, D. C., Vale, F. L., Dhandapani, K. M., Kolhe, R. & Vaibhav, K., May 2026, In: Neurochemistry International. 195, 106136.

Research output: Contribution to journal › Article › peer-review

​

Evaluating tocilizumab in ischemic stroke: Findings from the SPAN multicenter trial

Chauhan, A., Lee, E. A., Patel, R. B., Kumskova, M., Leira, E. C., Chauhan, A. K., Shi, Y., Cao, S., Koehler, R. C., Dhandapani, K. M., Khan, M. B., Kamat, P. K., Arbab, A., Hess, D. C., Herman, A. L., Boisserand, L., Sansing, L. H., Morais, A., Jin, X. & Aykan, S. & 8 others, Imai, T., Ayata, C., Nagarkatti, K. A., Lamb, J., Diniz, M. A., Lyden, P. D., McCullough, L. D. & Aronowski, J., Mar 1 2026, In: Neuropharmacology. 285, 110801.

Research output: Contribution to journal › Article › peer-review

​

Current best medical practices survey in vagus nerve stimulation programming

Moore-Hill, D. T., Butler, M., Weiss, D. L., Hill, L. A. T., Smith, H., Pope, B., McIntosh, C., Debs, L., Mbonde, A. A., Murro, A. M. & Vale, F. L., Mar 2026, In: Epilepsy and Behavior Reports. 33, 100849.

Research output: Contribution to journal › Article › peer-review

​

Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation

Wang, L. P., Bhandari, B., Naeini, S. E., Hill, B., Rogers, H. M., Gouron, J., Perez-Morales, N., Khan, A., Meeks, W., El-Marakby, A., Young, N., Vale, F. L., Ali, S., Wallace, G., Yu, J. C., Arbab, A. S., Salles, É. L. & Baban, B., Jan 2026, In: International journal of molecular sciences. 27, 2, 757.

Research output: Contribution to journal › Article › peer-review

​

Delivery management and related complications in pregnant women with brain arteriovenous malformation: A systematic review

Arjipour, M., Rezaei, M., Yeganeh, S. A., Sabahi, M., Irani, A. D. & Rahimi, S. Y., Jan 2026, In: World Neurosurgery: X. 29, 100551.

Research output: Contribution to journal › Review article › peer-review

​

First reported case of abdominal Nocardia pseudocyst in the setting of a ventriculoperitoneal shunt: a case report and review of literature

Cliett, J., Lee, M., Vale, F. & Macomson, S., Dec 2025, In: Journal of Medical Case Reports. 19, 1, 572.

Research output: Contribution to journal › Article › peer-review

​

Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach 3.0

Gaur, P., Ahluwalia, M., Ahluwalia, P. & Vaibhav, K., Dec 2025, In: Biomedicines. 13, 12, 3096.

Research output: Contribution to journal › Editorial › peer-review

​

Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network

Boisserand, L. S. B., Herman, A. L., Sanganahalli, B. G., Mihailovic, J., Beatty, H. E., Johnson, C. W., Diaz, S., DeLong, J. H., Velazquez, S., Grutzendler, J., Dela Cruz, C., Zhou, J., Sheth, K. N., Matouk, C., Zhan, S., Morais, A., Imai, T., Chauhan, A., Patel, R. B. & Kumskova, M. & 19 others, Shi, Y., Avery, B. D., Lamb, J., Nagarkatti, K. A., Khan, M. B., Kamat, P. K., Dhandapani, K. M., McCullough, L. D., Aronowski, J., Hess, D., Koehler, R. C., Lyden, P., Leira, E. C., Chauhan, A. K., Ayata, C., Chen, M. H., Diniz, M. A., Hyder, F. & Sansing, L. H., Nov 18 2025, In: Stroke. 56, 11, p. 3280-3293 14 p.

Research output: Contribution to journal › Article › peer-review

​

The origins of neurosurgery at the University of South Florida in Tampa Bay

Piper, K., Kumar, J. I., Smith, D., Freeman, T., Vale, F. L., Greenberg, M., Balis, G. & Van Loveren, H., Oct 2025, In: Journal of neurosurgery. 143, 4, p. 1121-1127 7 p.

Research output: Contribution to journal › Article › peer-review

​

Tipping point in middle meningeal artery embolization: a cost-effectiveness and algorithm-based analysis

Debs, L. H., Rahimi, S. Y. & Vale, F. L., Oct 2025, In: Neurosurgical focus. 59, 4, E10.

Research output: Contribution to journal › Article › peer-review

​

Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib

behalf of the SPAN investigators, Sep 25 2025, In: Journal of the American Heart Association. 14, 19, e040914.

Research output: Contribution to journal › Article › peer-review

​

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

Carretero, V. J., Álvarez-Merz, I., Hernández-Campano, J., Kirov, S. A. & Hernández-Guijo, J. M., Sep 1 2025, In: Neural Regeneration Research. 20, 9, p. 2454-2463 10 p.

Research output: Contribution to journal › Review article › peer-review

​

Surgery for mesial temporal pathology: a 26-year experience

Oliver, T. A., Lee, M. L., Piper, K. F., Ali, M. S. & Vale, F. L., Sep 2025, In: Journal of neurosurgery. 143, 3, p. 738-747 10 p.

Research output: Contribution to journal › Article › peer-review

​

Determinants of Outcome After Endovascular Middle Cerebral Artery Occlusion in Rats in the SPAN Trial

Jin, X., Morais, A., Imai, T., Lamb, J., Nagarkatti, K., Boisserand, L., Beatty, H. E., Sansing, L. H., Khan, M. B., Dhandapani, K., Kamat, P., Hess, D. C., Patel, R. B., Kumskova, M., Chauhan, A. K., McCullough, L. D., Aronowski, J., Leira, E. C., Shi, Y. & Avery, B. D. & 3 others, Koehler, R. C., Lyden, P. D. & Ayata, C., Sep 2025, In: Stroke. 56, 9, p. 2734-2747 14 p.

Research output: Contribution to journal › Article › peer-review

​

SOFIA Aspiration System as first-line Technique (SOFAST): a prospective, multicenter study to assess the efficacy and safety of the 6 French SOFIA Flow Plus aspiration catheter for endovascular stroke thrombectomy

Gandhi, D., Chen, H., Zaidi, S., Sahlein, D. H., Maidan, L., Kreitel, K., Miller, T. R., Rahimi, S., Shekhlee, A. A., Woo, H. H., Toth, G., Schirmer, C., Loh, Y. & Fiorella, D., Jul 1 2025, In: Journal of NeuroInterventional Surgery. 17, 7, p. 753-758 6 p.

Research output: Contribution to journal › Article › peer-review

​

Randomized Clinical Trials in Cerebrovascular Neurosurgery: Analysis of Discontinuation and Nonpublication Prevalence and Trends

Butler, M., Kaoutzani, L. & Rahimi, S., Jul 2025, In: World Neurosurgery. 199, 124159.

Research output: Contribution to journal › Article › peer-review

​

Subependymal giant cell astrocytoma in the absence of tuberous sclerosis complex: illustrative case

Ledford, W. L., Carr, C. J., Alfaro, M. G., Conger, C., Sharma, S., Henson, J. W. & Nguyen, K. D., Jul 2025, In: Journal of Neurosurgery: Case Lessons. 10, 1, CASE2566.

Research output: Contribution to journal › Article › peer-review

​

Neuropsychological outcomes of hippocampus-sparing anterior temporal lobectomy versus stereotactic laser amygdalohippocampectomy in language-dominant temporal lobe epilepsy

George, Z., Piper, K., Neal, E. G., Alayli, A., Schimmel, S., Monsour, M., Di, L., Amin, U., Boscarino, J. J., Schoenberg, M. R., Vale, F. L. & Bezchlibnyk, Y. B., Jul 2025, In: Epilepsia. 66, 7, p. 2465-2479 15 p.

Research output: Contribution to journal › Article › peer-review

​

Endoscopic endonasal obliteration of the frontal recess and anterior skull base

Peto, I., Alexander, B., Krafft, P., VAN LOVEREN, H., Agazzi, S., Vale, F. L. & Tabor, M. H., Jun 2025, In: Journal of Neurosurgical Sciences. 69, 3, p. 290-296 7 p.

Research output: Contribution to journal › Article › peer-review

​

NORSE secondary to anti-GAD65 antibody-positive encephalitis treated with novel adjunctive rapid titration VNS protocol

Li, M., Yalcin, N., Weiss, D. L., Hill, L. A. T., Shah, M., Garcia, K. A., Vale Diaz, F. L., Rueda Carrillo, L. G., Smith, H. & Moore-Hill, D. T., Apr 2025, In: Epilepsia Open. 10, 2, p. 581-586 6 p.

Research output: Contribution to journal › Article › peer-review

​

Acute-Phase Recording of the Spreading Depolarization Continuum in Aged Nonhuman Primates during Focal Ischemic Stroke

Sword, J. J., Sparks, T., Debs, L. H., Major, S., Sharma, S. J., Jensen, M. A., Moore-Hill, D. T., Barton, K., Shah, M., Garcia, K. A., Switzer, J. A., Blake, D. T., Vale, F. L., Dreier, J. P., Hartings, J. A. & Kirov, S. A., Apr 1 2025, In: Stroke. 56, 4, p. 974-986 13 p.

Research output: Contribution to journal › Article › peer-review

​

Pesticide Exposure in Agricultural Workplaces and Resultant Health Effects in Women

Kumar, S. N., Khan, N. H., Reda, Y., Beigh, H. H., Bastia, B., Vaibhav, K., Jain, A. K. & Raisuddin, S., Apr 2025, In: Birth Defects Research. 117, 4, e2460.

Research output: Contribution to journal › Review article › peer-review

​

Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial

Patel, R. B., Kumskova, M., Kodali, H., Budnik, I., Kuznetsov, V., Jain, A., Jha, A., Thedens, D., Dhanesha, N., Sutariya, B., Nagarkatti, K. A., Lamb, J., Kamat, P., Shi, Y., Avery, B., Imai, T., Jin, X., Chauhan, A., Boisserand, L. S. B. & Khan, M. B. & 14 others, Dhandapani, K., Sanganahalli, B. G., Sansing, L. H., Hess, D. C., Koehler, R. C., McCullough, L. D., Aronowski, J., Ayata, C., Diniz, M. A., Lyden, P. D., Planas, A. M., Chamorro, A., Chauhan, A. K. & Leira, E. C., Apr 1 2025, In: Stroke. 56, 4, p. 965-973 9 p.

Research output: Contribution to journal › Article › peer-review

​

Analysis of participant race and sex reporting and disparities in US epilepsy clinical trials

Butler, M., Palacios, M. E., Carr, C., Moore-Hill, D. & Vale, F. L., Mar 2025, In: Epilepsia. 66, 3, p. 768-775 8 p.

Research output: Contribution to journal › Article › peer-review

​

Right-sided vagus nerve stimulation: Worldwide collection and perspectives

Zanello, M., Voges, B., Chelvarajah, R., Sen, A., Petelin Gadže, Ž., Penchet, G., De Benedictis, A., Fornaro, R., Iwasaki, M., Iijima, K., Jiltsova, E., Mrak, G., Barrit, S., Moiraghi, A., Landi, A., Neale, M., Magdum, S., Caire, F., Godet, B. & Domenech, P. & 12 others, Gaillard, R., Guenot, M., Labuschagne, J., Rainha Campos, A., Rooijakkers, H., El Tahry, R., Von Hertwig Fernandes De Oliveira, T., Alvarez-Sala, A., Torres, C. V., Vale, F., Pallud, J. & Carron, R., Mar 2025, In: Annals of Clinical and Translational Neurology. 12, 3, p. 565-576 12 p.

Research output: Contribution to journal › Article › peer-review

​

Robot-assisted MRI-guided laser interstitial thermal therapy for a giant sessile hypothalamic hamartoma in an 8-year-old boy: illustrative case

Butler, M., Carr, C., Baker, D., Bhatia, A., Vale, F. L. & Nguyen, K., Mar 2025, In: Journal of Neurosurgery: Case Lessons. 9, 9, CASE24628.

Research output: Contribution to journal › Article › peer-review

​

Basal forebrain activation improves working memory in senescent monkeys

Pennington, K. R., Debs, L., Chung, S., Bava, J., Garin, C. M., Vale, F. L., Bick, S. K., Englot, D. J., Terry, A. V., Constantinidis, C. & Blake, D. T., Mar 1 2025, In: Brain Stimulation. 18, 2, p. 185-194 10 p.

Research output: Contribution to journal › Article › peer-review

​

Cortical acetylcholine response to deep brain stimulation of the basal forebrain in mice

Shanazz, K., Xie, K., Oliver, T., Bogan, J., Vale, F. L., Sword, J. J., Kirov, S. A., Terry, A., O’Herron, P. & Blake, D. T., Mar 2025, In: Journal of Neurophysiology. 133, 3, p. 825-838 14 p.

Research output: Contribution to journal › Article › peer-review

​

Time of day dependent reduction in stroke infarct volume by the Reverb agonist SR9009 in mice

Kamat, P. K., Khan, M. B., Siddiqui, S., Hattaway, T. G., Anas, A., Rudic, R. D., Baban, B., Dhandapani, K. M. & Hess, D. C., Feb 2025, In: Experimental Neurology. 384, 115067.

Research output: Contribution to journal › Article › peer-review

​

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology

Gaur, P., Vaibhav, K., Ahluwalia, M. & Gupta, S., 2025, In: Frontiers in Molecular Neuroscience. 18, 1607675.

Research output: Contribution to journal › Editorial › peer-review

​

Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literature

Butler, M., Carr, C., Mehra, M., Barnett, A. M., Salley, J., Chauhan, A., Belakhlef, S., Wallace, G. C., Rutkowski, M., Vender, J. & Vale, F. L., 2025, In: Surgical Neurology International. 16, 136.

Research output: Contribution to journal › Article › peer-review

​

A systematic review of the role of wearable devices and artificial intelligence applications in assessing functional outcomes after lumbar fusion

Sripadrao, S., Carr, C., Quraishi, M., Abes, J., Mehra, M., James, K., Vale, F. & Pare, M., 2025, (Accepted/In press) In: Spine Journal.

Research output: Contribution to journal › Review article › peer-review

​

Optimization of seizure prevention by cannabidiol (CBD)

Bhandari, B., Naeini, S. E., Rezaee, S., Rogers, H. M., Khodadadi, H., Bosomtwi, A., Seyyedi, M., Mackinnon, N. J., Dhandapani, K. M., Salles, É. L., Hess, D. C., Yu, J. C., Moore-Hill, D., Vale, F. L., Wang, L. P. & Baban, B., Jan 1 2025, In: Translational Neuroscience. 16, 1, 20220362.

Research output: Contribution to journal › Article › peer-review

​

Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke

Alptekin, A., Khan, M. B., Parvin, M., Chowdhury, H., Kashif, S., Selina, F. A., Bushra, A., Kelleher, J., Ghosh, S., Williams, D., Blumling, E., Ara, R., Bosomtwi, A., Frank, J. A., Dhandapani, K. M. & Arbab, A. S., 2025, In: Frontiers in Neurology. 16, 1543133.

Research output: Contribution to journal › Article › peer-review

​

Newer treatment paradigm improves outcomes in the most common neurosurgical disease of the elderly: a literature review of middle meningeal artery embolization for chronic subdural hematoma

Debs, L. H., Walker, S. E. & Rahimi, S. Y., Dec 2024, In: GeroScience. 46, 6, p. 6537-6561 25 p.

Research output: Contribution to journal › Review article › peer-review

​

Spreading depolarization causes reversible neuronal mitochondria fragmentation and swelling in healthy, normally perfused neocortex

Sword, J. J., Fomitcheva, I. V. & Kirov, S. A., Dec 2024, In: Journal of Cerebral Blood Flow and Metabolism. 44, 12, p. 1561-1579 19 p.

Research output: Contribution to journal › Article › peer-review

​

Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease

Khodadadi, H., Salles, É. L., Naeini, S. E., Bhandari, B., Rogers, H. M., Gouron, J., Meeks, W., Terry, A. V., Pillai, A., Yu, J. C., Morgan, J. C., Vaibhav, K., Hess, D. C., Dhandapani, K. M., Wang, L. P. & Baban, B., Nov 2024, In: International journal of molecular sciences. 25, 21, 11764.

Research output: Contribution to journal › Article › peer-review

​

Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach 2.0

Ahluwalia, P., Gaur, P., Ahluwalia, M. & Vaibhav, K., Nov 2024, In: Biomedicines. 12, 11, 2586.

Research output: Contribution to journal › Editorial › peer-review

​

Middle meningeal artery embolization following surgical evacuation of symptomatic chronic subdural hematoma improves outcomes, interim results of a prospective randomized trial

Debs, L. H., Vale, F. L., Walker, S., Toro, D., Mansouri, S., Macomson, S. D. & Rahimi, S. Y., Oct 2024, In: Journal of Clinical Neuroscience. 128, 110783.

Research output: Contribution to journal › Article › peer-review

​

Pipeline Embolization Device and Flow Re-Direction Endoluminal Device for Intracranial Aneurysms: A Comparative Systematic Review and Meta-Analysis Study

Rashidi, F., Habibi, M. A., Reyhani, M., Fallahi, M. S., Arshadi, M. R., Sabahi, M., Vakharia, K. & Rahimi, S. Y., Sep 2024, In: World Neurosurgery. 189, p. 399-409.e18

Research output: Contribution to journal › Review article › peer-review

View All Publications.

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