Our lab is interested to better understand processes affecting puberty, fertility, and human development. With an emphasis on translational medicine, we hope to identify genes important for the development of normal puberty, sexual differentiation, and other organs including the heart and brain. In addition we want to optimize the outcome for patients with infertility, pregnancy loss, and assisted reproductive technologies, as well as reducing the likelihood of birth defects. Most recently, we received NIH grant funding for a project to identify genes involved in uterine and vaginal development.
Dr. Layman
706-721-3832; 706-721-7591
706-721-6830; 706-721-0340
MCG
DNRM/ OB/GYN
1120 15th Street, CA-2041
Augusta, GA 30912
Participate in one of Dr. Layman's Research Studies
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
Kim YJ, Osborn DP, Lee JY, Araki M, Araki K, Mohun T, Känsäkoski J, Brandstack N, Kim HT, Miralles F, Kim CH, Brown NA, Kim HG, Martinez-Barbera JP, Ataliotis P, Raivio T, Layman LC, Kim SH. WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289. doi: 10.15252/embr.201744632. Epub 2017 Dec 20. PubMed PMID: 29263200; PubMed Central PMCID: PMC5797970.
Genetic analysis of Mayer-Rokitansky-Kuster-Hauser syndrome in a large cohort of families
Williams LS, Demir Eksi D, Shen Y, Lossie AC, Chorich LP, Sullivan ME, Phillips JA 3rd, Erman M, Kim HG, Alper OM, Layman LC. Genetic analysis of Mayer-Rokitansky-Kuster-Hauser syndrome in a large cohort of families. Fertil Steril. 2017 Jul;108(1):145-151.e2. doi: 10.1016/j.fertnstert.2017.05.017. Epub 2017 Jun 7. PubMed PMID: 28600106; PubMed Central PMCID: PMC5770980.
JAK/STAT signaling pathway gene expression is reduced following Nelf knockdown in GnRH neurons
Ko EK, Chorich LP, Sullivan ME, Cameron RS, Layman LC. JAK/STAT signaling pathway gene expression is reduced following Nelf knockdown in GnRH neurons. Mol Cell Endocrinol. 2017 Oct 16. pii: S0303-7207(17)30546-4. doi:10.1016/j.mce.2017.10.009. [Epub ahead of print] PubMed PMID: 29050862.
A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3
Williams LS, Kim HG, Kalscheuer VM, Tuck JM, Chorich LP, Sullivan ME, Falkenstrom A, Reindollar RH, Layman LC. A balanced chromosomal translocation involving chromosomes 3 and 16 in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome reveals new candidate genes at 3p22.3 and 16p13.3. Mol Cytogenet. 2016 Jul 30;9:57. doi: 10.1186/s13039-016-0264-6. eCollection 2016. PubMed PMID:27478502; PubMed Central PMCID: PMC4967518.
Targeted next generation sequencing approach identifies eighteen new candidate genes in normosmic hypogonadotropic hypogonadism and Kallmann syndrome
Quaynor SD, Bosley ME, Duckworth CG, Porter KR, Kim SH, Kim HG, Chorich LP,Sullivan ME, Choi JH, Cameron RS, Layman LC. Targeted next generation sequencing approach identifies eighteen new candidate genes in normosmic hypogonadotropic hypogonadism and Kallmann syndrome. Mol Cell Endocrinol. 2016 Aug 5;437:86-96.doi: 10.1016/j.mce.2016.08.007. PubMed PMID: 27502037.
NELF knockout is associated with impaired pubertal development and subfertility. Mol Cell Endocrinol
Quaynor SD, Ko EK, Chorich LP, Sullivan ME, Demir D, Waller JL, Kim HG, Cameron RS, Layman LC. NELF knockout is associated with impaired pubertal development and subfertility. Mol Cell Endocrinol. 2015 May 15;407:26-36. doi: 10.1016/j.mce.2015.02.015. Epub 2015 Feb 27. PubMed PMID: 25731822; PubMed Central PMCID: PMC4429764.
Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant
Quaynor SD, Stradtman EW Jr, Kim HG, Shen Y, Chorich LP, Schreihofer DA, Layman LC. Delayed puberty and estrogen resistance in a woman with estrogen receptor α variant. N Engl J Med. 2013 Jul 11;369(2):164-71. doi: 10.1056/NEJMoa1303611. PubMed PMID: 23841731; PubMed Central PMCID: PMC3823379.
Clinical genetic testing for Kallmann syndrome
Layman LC. Clinical genetic testing for Kallmann syndrome. J Clin Endocrinol Metab. 2013 May;98(5):1860-2. doi: 10.1210/jc.2013-1624. PubMed PMID: 23650337; PubMed Central PMCID: PMC3644595.
