Associate Professor
Department of Cellular Biology and Anatomy
Office: R&E Building CB2815
Research Laboratory CB2905
Phone: 706-721-6772
Fax: 706-721-6120
envelope-o icon mzhang@augusta.edu
1992 - Tongji Medical University, PhD.; Specialty: Pediatric Infectious Diseases
1988 - Tongji Medical University, MS; Specialty: Pediatric Infectious Diseases
1985 - Hubei Medical University, MD; Specialty: Medicine
1996 - 2000 - Dept. of Cellular and Structural Biology, Univ. of Texas Health Science Center at San Antonio
1992 -1995 - Division of infectious diseases, Dept. of Pediatrics, Tongji Hospital, Tongji Medical University, China
The primary objective of our research program is to understand the pathogenesis of cytomegalovirus and herpes simplex virus ocular infections by using mouse models and organatypic retinal culture models. Our current work includes the investigation of the mechanisms of death of bystander retinal cells during ocular murine cytomegalovirus retinitis and also determine the role of cytomegalovirus in the development of age-related macular degeneration (AMD).
Principal Investigator: NIH, NEI, RO1, "Mechanism of death of bystander retinal cells
during MCMV infection."
Principal Investigator: Bright Focus Foundation, Macular Degeneration Research award,
"The role of cytomegalovirus in the development of neovascular age-related macular
degeneration (AMD)."
Ma Z, Li L, Livingston MJ, Zhang D, Mi Q, Zhang M, Ding HF, Huo Y, Mei C, Dong Z. p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease. J Clin Invest. 2020 Sep 1;130(9):5011-5026. doi: 10.1172/JCI135536. PubMed PMID: 32804155; PubMed Central PMCID: PMC7456229.
Xu J, Liu X, Zhang X, Marshall B, Dong Z, Liu Y, Espinosa-Heidmann DG, Zhang M. Ocular cytomegalovirus latency exacerbates the development of choroidal neovascularization. J Pathol. 2020 Jun;251(2):200-212. doi: 10.1002/path.5447. Epub 2020 May 21. PubMed PMID: 32243583; PubMed Central PMCID: PMC7356643.
Yang H, Li R, Zhang L, Zhang S, Dong W, Chen Y, Wang W, Li C, Ye Z, Zhao X, Li Z, Wu Y, Zhang M, Liu S, Dong Z, Liang X. p53-cyclophilin D mediates renal tubular cell apoptosis in ischemia-reperfusion-induced acute kidney injury. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1311-F1317. doi: 10.1152/ajprenal.00072.2019. Epub 2019 Jul 24. PubMed PMID: 31339772.
Wei Q, Su J, Dong G, Zhang M, Huo Y, Dong Z. Glycolysis inhibitors suppress renal interstitial fibrosis via divergent effects on fibroblasts and tubular cells. Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1162-F1172. doi: 10.1152/ajprenal.00422.2018. Epub 2019 Apr 10. PubMed PMID: 30969803; PubMed Central PMCID: PMC6620587.
Ma Z, Wei Q, Zhang M, Chen JK, Dong Z. Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1822-F1832. doi: 10.1152/ajprenal.00402.2018. Epub 2018 Oct 3. PubMed PMID: 30280598; PubMed Central PMCID: PMC6337000.
Xu J, Liu X, Mo J, Marshall B, Perry L, Dong Z, Zhang M. Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections. Mol Vis. 2018;24:379-394. eCollection 2018. PubMed PMID: 29853772; PubMed Central PMCID: PMC5957546.
Xu J, Mo J, Liu X, Marshall B, Atherton SS, Dong Z, Smith S, Zhang M. Depletion of the Receptor-Interacting Protein Kinase 3 (RIP3) Decreases Photoreceptor Cell Death During the Early Stages of Ocular Murine Cytomegalovirus Infection. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2445-2458. doi: 10.1167/iovs.18-24086. PubMed PMID: 29847649; PubMed Central PMCID: PMC5957522.
Yang D, Livingston MJ, Liu Z, Dong G, Zhang M, Chen JK, Dong Z. Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential. Cell Mol Life Sci. 2018 Feb;75(4):669-688. doi: 10.1007/s00018-017-2639-1. Epub 2017 Sep 4. Review. PubMed PMID: 28871310; PubMed Central PMCID: PMC5771948.
Zhou X, Zhang W, Yao Q, Zhang H, Dong G, Zhang M, Liu Y, Chen JK, Dong Z. Exosome production and its regulation of EGFR during wound healing in renal tubular cells. Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F963-F970. doi: 10.1152/ajprenal.00078.2017. Epub 2017 Mar 29. PubMed PMID: 28356285; PubMed Central PMCID: PMC5495889.
Mo J, Marshall B, Covar J, Zhang NY, Smith SB, Atherton SS, Zhang M. Role of Bax in death of uninfected retinal cells during murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2014 Oct 8;55(11):7137-46. doi: 10.1167/iovs.14-15404. PubMed PMID: 25298417; PubMed Central PMCID: PMC4224579.
Mo J, Zhang M, Marshall B, Smith S, Covar J, Atherton S. Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells. Mol Vis. 2014;20:1161-73. eCollection 2014. PubMed PMID: 25324684; PubMed Central PMCID: PMC4145064.
Marshall B, Mo J, Covar J, Atherton SS, Zhang M. Decrease of murine cytomegalovirus-induced retinitis by intravenous delivery of immediate early protein-3-specific siRNA. Invest Ophthalmol Vis Sci. 2014 Jun 6;55(7):4151-7. doi: 10.1167/iovs.14-14375. PubMed PMID: 24906861; PubMed Central PMCID: PMC4089418.
Zhang M, Covar J, Zhang NY, Chen W, Marshall B, Mo J, Atherton SS. Virus spread and immune response following anterior chamber inoculation of HSV-1 lacking the Beclin-binding domain (BBD). J Neuroimmunol. 2013 Jul 15;260(1-2):82-91. doi: 10.1016/j.jneuroim.2013.03.013. Epub 2013 Apr 21. PubMed PMID: 23611643; PubMed Central PMCID: PMC3679340.
Marshall B, Zhang M, Atherton SS. The effect of murine cytomegalovirus IE-3 specific shRNA is dependent on intragenic target site due to multiple transcription initiation sites. Herpesviridae. 2011 Sep 18;2(1):9. doi: 10.1186/2042-4280-2-9. PubMed PMID: 21923934; PubMed Central PMCID: PMC3192721.
Gnana-Prakasam JP, Ananth S, Prasad PD, Zhang M, Atherton SS, Martin PM, Smith SB, Ganapathy V. Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3751-8. doi: 10.1167/iovs.10-6722. PubMed PMID: 21357408; PubMed Central PMCID: PMC3109050.
Zhang M, Covar J, Marshall B, Dong Z, Atherton SS. Lack of TNF-alpha promotes caspase-3-independent apoptosis during murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2011 Mar 28;52(3):1800-8. doi: 10.1167/iovs.10-6904. PubMed PMID: 21310911; PubMed Central PMCID: PMC3101684.
Gnana-Prakasam JP, Zhang M, Martin PM, Atherton SS, Smith SB, Ganapathy V. Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection. Biochem J. 2009 May 1;419(3):533-43. doi: 10.1042/BJ20082240. PubMed PMID: 19191760.
Zhang M, Marshall B, Atherton SS. Murine cytomegalovirus infection and apoptosis in organotypic retinal cultures. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):295-303. doi: 10.1167/iovs.07-0612. PubMed PMID: 18172106; PubMed Central PMCID: PMC3964603.
Zhou J, Zhang M, Atherton SS. Tumor necrosis factor-alpha-induced apoptosis in murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1691-700. doi: 10.1167/iovs.06-1040. PubMed PMID: 17389501.
Zhang M, Zhou J, Marshall B, Xin H, Atherton SS. Lack of iNOS facilitates MCMV spread in the retina. Invest Ophthalmol Vis Sci. 2007 Jan;48(1):285-92. doi: 10.1167/iovs.06-0792. PubMed PMID: 17197545.
Fields M, Zheng M, Zhang M, Atherton SS. Tumor necrosis factor alpha and macrophages in the brain of herpes simplex virus type 1-infected BALB/c mice. J Neurovirol. 2006 Dec;12(6):443-55. doi: 10.1080/13550280601039030. PubMed PMID: 17162660.
Zhang M, Xin H, Atherton SS. Murine cytomegalovirus (MCMV) spreads to and replicates in the retina after endotoxin-induced disruption of the blood-retinal barrier of immunosuppressed BALB/c mice. J Neurovirol. 2005 Aug;11(4):365-75. doi: 10.1080/13550280591002432. PubMed PMID: 16162479.
Zhang M, Xin H, Roon P, Atherton SS. Infection of retinal neurons during murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2047-55. doi: 10.1167/iovs.05-0005. PubMed PMID: 15914622.
Zhang M, Xin H, Duan Y, Atherton SS. Ocular reactivation of MCMV after immunosuppression of latently infected BALB/c mice. Invest Ophthalmol Vis Sci. 2005 Jan;46(1):252-8. doi: 10.1167/iovs.04-0537. PubMed PMID: 15623781.
Zhang M, Atherton SS. Apoptosis in the retina during MCMV retinitis in immunosuppressed BALB/c mice. J Clin Virol. 2002 Aug;25 Suppl 2:S137-47. doi: 10.1016/s1386-6532(02)00102-6. PubMed PMID: 12361764.
Bigger JE, Tanigawa M, Zhang M, Atherton SS. Murine cytomegalovirus infection causes apoptosis of uninfected retinal cells. Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2248-54. PubMed PMID: 10892869..
Tan DX, Manchester LC, Reiter RJ, Qi WB, Zhang M, Weintraub ST, Cabrera J, Sainz RM, Mayo JC. Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. Biochim Biophys Acta. 1999 Oct 18;1472(1-2):206-14. doi: 10.1016/s0304-4165(99)00125-7. PubMed PMID: 10572942.
