Research in the biological sciences gives students a broader appreciation for their field of study. Research is an excellent way to develop problem-solving and creative thinking skills. In the process, students benefit from increased interactions with fellow students and faculty while they gain confidence through hands-on, real-world experiences in the field and in the lab.

AU Students have the opportunity to present their findings on campus and at regional and national meetings. Meetings include the Georgia Academy of Sciences Conference, the Association of Southeastern Biologists (ASB) Meeting, the Southeastern Estuarine Research Society (SEERS) Meeting, and the Southeastern Regional Yeast Meeting (SERYM), among others. In addition, the Augusta University chapter of Phi Kappa Phi hosts an annual, campus-wide research conference where students present their findings in poster format and oral presentations to the Augusta community.

Throughout the year, the Center for Undergraduate Research and Scholarship hosts the Brown Bag Series where Augusta University students from all disciplines present their research.

Contact Us

Biological Sciences

Health Sciences Campus

Science & Mathematics Building

706-737-1539

biology@augusta.edu

The Goldstein Lab

The Goldstein Lab the pathogenesis and repair of diffuse white matter injury – the most common neuropathological outcome of premature birth.

Research Interests: Brain Injury / Myelin / Epigenetics / 

https://www.augusta.edu/scimath/biological-sciences/goldstein-research-page.php 

Creativity, Discovery, Engagement

Publications

Publication

Amino acid restriction, aging, and longevity: an update

Austad, S. N., Smith, J. R. & Hoffman, J. M., 2024, In: Frontiers in Aging. 5, 1393216.

Research output: Contribution to journalReview articlepeer-review

The companion dog as a model for inflammaging: a cross-sectional pilot study

Schmid, S. M., Hoffman, J. M., Prescott, J., Ernst, H., Promislow, D. E. L. & Creevy, K. E., 2024, (Accepted/In press) In: GeroScience.

Research output: Contribution to journalArticlepeer-review

Clippers are superior to scissors in the collection of hair for chemical analysis in companion dogs: a Dog Aging Project preliminary study

Ditzler, B., Evans, J. B., Illing, K., Kaeberlein, M., Promislow, D. E. L., Brindle, E., Hoffman, J. M. & Creevy, K. E., May 2024, In: American Journal of Veterinary Research. 85, 5, p. 1-7 7 p.

Research output: Contribution to journalArticlepeer-review

THE BENEFITS OF A PHYSICAL THERAPY PROGRAM AMONG BREAST CANCER PATIENTS WHO HAVE UNDERGONE A MASTECTOMY

Asbury, E., Bennett, H., Cannon, J. & Kindred, M., 2024, In: Journal of Cancer Rehabilitation. 7, 2, p. 80-92 13 p.

Research output: Contribution to journalArticlepeer-review

Absence of MMF1 disrupts heme biosynthesis by targeting Hem1pin Saccharomyces cerevisiae

Whitaker, G. H., Ernst, D. C. & Downs, D. M., Dec 2021, In: Yeast. 38, 12, p. 615-624 10 p.

Research output: Contribution to journalArticlepeer-review

Gut Microbiome Transplants and Their Health Impacts across Species

Levine, B. H. & Hoffman, J. M., Jun 2023, In: Microorganisms. 11, 6, 1488.

Research output: Contribution to journalReview articlepeer-review

Lactating SKH-1 furless mice prioritize own comfort over growth of their pups

Hoffman, J. M., Schmitz, B., Pfabe, J. U., Ohrnberger, S. A. & Valencak, T. G., Aug 2023, In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 193, 4, p. 453-459 7 p.

Research output: Contribution to journalArticlepeer-review

Blockade of interleukin-6 trans-signaling prevents mitochondrial dysfunction and cellular senescence in retinal endothelial cells

Hoffman, J. M., Robinson, R., Greenway, G., Glass, J., Budkin, S. & Sharma, S., Dec 2023, In: Experimental eye research. 237, 109721.

Research output: Contribution to journalArticlepeer-review

Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques

Stout, M. B., Vaughan, K. L., Isola, J. V. V., Mann, S. N., Wellman, B., Hoffman, J. M., Porter, H. L., Freeman, W. M. & Mattison, J. A., Aug 2023, In: GeroScience. 45, 4, p. 2337-2349 13 p.

Research output: Contribution to journalArticlepeer-review

Production of a p65fl/fl/LysMCre mouse model with dysfunctional NF-κB signaling in bone marrow-derived macrophages

Korkaya, A. K., Fischer, J., Peppers, A., Crosson, S. M., Rayamajhi, M., Miao, E. A., Baldwin, A. S. & Bradford, J. W., Nov 2023, In: Innate Immunity. 29, 8, p. 171-185 15 p.

Research output: Contribution to journalArticlepeer-review

Orchiectomy sensitizes cortical bone in male mice to the harmful effects of kynurenine

Bensreti, H., Yu, K., Alhamad, D. W., Shaver, J., Kaiser, H., Zhong, R., Whichard, W. C., Parker, E., Grater, L., Faith, H., Johnson, M., Cooley, M. A., Fulzele, S., Hill, W. D., Isales, C. M., Hamrick, M. W. & McGee-Lawrence, M. E., Aug 2023, In: Bone. 173, 116811.

Research output: Contribution to journalArticlepeer-review

Cyclic Nucleotides as Mediators of Acinar and Ductal Function

Albers, T. & Sabbatini, M. E., 2021, Cyclic Nucleotides as Mediators of Acinar and Ductal Function. Pancreapedia

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Characterizing the NADPH Oxidase 1-Evoked Pancreatic Stellate Cell Secretome

Chakraborty, A., Souravi, M., Zhi, W., Csanyi, G. & Sabbatini, M., 2021, In: The Arsenal: The Undergraduate Research Journal of Augusta University. 4, 1, p. 6-6 1 p.

Research output: Contribution to journalArticlepeer-review

Targeting tumor microenvironment-associated cells to reverse therapy resistance

Piranlioglu, R., Bradford, J. W. & Arbab, A. S., Jan 1 2021, New Targeting in the Reversal of Resistant Glioblastomas. Elsevier, p. 115-144 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sulforaphane has an additive anticancer effect to FOLFOX in highly metastatic human colon carcinoma cells

Čižauskaitė, A., Šimčikas, D., Schultze, D., Kallifatidis, G., Bruns, H., Čekauskas, A., Herr, I., Baušys, A., Strupas, K. & Schemmer, P., Nov 2022, In: Oncology Reports. 48, 5, 205.

Research output: Contribution to journalArticlepeer-review

A longitudinal analysis of the effects of age on the blood plasma metabolome in the common marmoset, Callithrix jacchus

Hoffman, J. M., Tran, V. L., Wachtman, L. M., Green, C. L., Jones, D. P. & Promislow, D. E. L., Apr 1 2016, In: Experimental Gerontology. 76, p. 17-24 8 p.

Research output: Contribution to journalArticlepeer-review

Invariance and plasticity in the Drosophila melanogaster metabolomic network in response to temperature

Hariharan, R., Hoffman, J. M., Thomas, A. S., Soltow, Q. A., Jones, D. P. & Promislow, D. E. L., Dec 24 2014, In: BMC Systems Biology. 8, 1, 139.

Research output: Contribution to journalArticlepeer-review

Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster

Hoffman, J. M., Soltow, Q. A., Li, S., Sidik, A., Jones, D. P. & Promislow, D. E. L., Aug 2014, In: Aging Cell. 13, 4, p. 596-604 9 p.

Research output: Contribution to journalArticlepeer-review

Canine hyperadrenocorticism associations with signalment, selected comorbidities and mortality within North American veterinary teaching hospitals

Hoffman, J. M., Lourenço, B. N., Promislow, D. E. L. & Creevy, K. E., Nov 2018, In: Journal of Small Animal Practice. 59, 11, p. 681-690 10 p.

Research output: Contribution to journalArticlepeer-review

Reproductive Capability Is Associated with Lifespan and Cause of Death in Companion Dogs

Hoffman, J. M., Creevy, K. E. & Promislow, D. E. L., Apr 17 2013, In: PloS one. 8, 4, e61082.

Research output: Contribution to journalArticlepeer-review

The companion dog as a model for the longevity dividend

Creevy, K. E., Austad, S. N., Hoffman, J. M., O’Neill, D. G. & Promislow, D. E. L., Jan 2016, In: Cold Spring Harbor perspectives in medicine. 6, 1

Research output: Contribution to journalArticlepeer-review

MicroRNA cargo of extracellular vesicles released by skeletal muscle fibro-adipogenic progenitor cells is significantly altered with disuse atrophy and IL-1b deficiency

Parker, E., Mendhe, B., Ruan, L., Marshall, B., Zhi, W., Liu, Y., Fulzele, S., Tang, Y. L., McGee-Lawrence, M., Lee, T. J., Sharma, A. K., Johnson, M., Chen, J. & Hamrick, M. W., Aug 2022, In: Physiological Genomics. 54, 8, p. 296-304 9 p.

Research output: Contribution to journalArticlepeer-review

Development of a novel purification protocol to isolate and identify brain microglia

Doughty, D., Rajpurohit, S. K., Trang, A., Alptekin, A., Korkaya, A. K., Achyut, B. R., Arbab, A. S. & Bradford, J. W., Aug 2022, In: Experimental Biology and Medicine. 247, 16, p. 1433-1446 14 p.

Research output: Contribution to journalArticlepeer-review

Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

Yang, L., Wu, C., Parker, E., Li, Y., Dong, Y., Tucker, L., Brann, D. W., Lin, H. W. & Zhang, Q., 2022, In: Theranostics. 12, 5, p. 2205-2231 27 p.

Research output: Contribution to journalArticlepeer-review

Long Non-coding RNA MALAT1 Is Depleted With Age in Skeletal Muscle in vivo and MALAT1 Silencing Increases Expression of TGF-β1 in vitro

Ruan, L., Mendhe, B., Parker, E., Kent, A., Isales, C. M., Hill, W. D., McGee-Lawrence, M., Fulzele, S. & Hamrick, M. W., Jan 21 2022, In: Frontiers in Physiology. 12, 742004.

Research output: Contribution to journalArticlepeer-review

Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy

Parker, E., Khayrullin, A., Kent, A., Mendhe, B., Youssef El Baradie, K. B., Yu, K., Pihkala, J., Liu, Y., McGee-Lawrence, M., Johnson, M., Chen, J. & Hamrick, M., Jan 3 2022, In: Frontiers in Cell and Developmental Biology. 9, 790437.

Research output: Contribution to journalArticlepeer-review

The Glucocorticoid Receptor in Osterix-Expressing Cells Regulates Bone Mass, Bone Marrow Adipose Tissue, and Systemic Metabolism in Female Mice During Aging

Pierce, J. L., Sharma, A. K., Roberts, R. L., Yu, K., Irsik, D. L., Choudhary, V., Dorn, J. S., Bensreti, H., Benson, R. D., Kaiser, H., Khayrullin, A., Davis, C., Wehrle, C. J., Johnson, M. H., Bollag, W. B., Hamrick, M. W., Shi, X., Isales, C. M. & McGee-Lawrence, M. E., Feb 2022, In: Journal of Bone and Mineral Research. 37, 2, p. 285-302 18 p.

Research output: Contribution to journalArticlepeer-review

Tachycardia evoked from insular stroke in rats is dependent on glutamatergic neurotransmission in the dorsomedial hypothalamus

Marins, F. R., Limborço-Filho, M., Iddings, J. A., Xavier, C. H., Biancardi, V. C., Stern, J. E., Ramiro Diaz, J., Oppenheimer, S. M., Filosa, J. A. & Peliky Fontes, M. A., Nov 2021, In: European Journal of Neurology. 28, 11, p. 3640-3649 10 p.

Research output: Contribution to journalArticlepeer-review

Mitochondrial DNA Haplotype Diversity in Two Portunid Populations Found along the Georgia and South Carolina Coasts

Abdulovic-Cui, A., Mannix, S., Coleman, A., White, B., Mingledolph, K. & Reichmuth, J. M., May 1 2021, In: Southeastern Naturalist. 20, 2, p. 367-376 10 p.

Research output: Contribution to journalArticlepeer-review

Arrb1 regulates metabolic reprogramming to promote glycolysis in stem cell-like bladder cancer cells

Mamouni, K., Kim, J., Lokeshwar, B. L. & Kallifatidis, G., Apr 2 2021, In: Cancers. 13, 8, 1809.

Research output: Contribution to journalArticlepeer-review

Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells

Al-Shabrawey, M., Hussein, K., Wang, F., Wan, M., Elmasry, K., Elsherbiny, N., Saleh, H., Yu, P. B., Tawfik, A. & Ibrahim, A. S., Jan 29 2021, In: Frontiers in immunology. 11, 568795.

Research output: Contribution to journalArticlepeer-review

Role of fibro-adipogenic progenitor cells in muscle atrophy and musculoskeletal diseases

Parker, E. & Hamrick, M. W., Jun 2021, In: Current Opinion in Pharmacology. 58, p. 1-7 7 p.

Research output: Contribution to journalReview articlepeer-review

Targeting mitochondrial metabolism in prostate cancer with triterpenoids

Mamouni, K., Kallifatidis, G. & Lokeshwar, B. L., Mar 1 2021, In: International journal of molecular sciences. 22, 5, p. 1-15 15 p., 2466.

Research output: Contribution to journalReview articlepeer-review

The role of β-arrestins in regulating stem cell phenotypes in normal and tumorigenic cells

Kallifatidis, G., Mamouni, K. & Lokeshwar, B. L., Dec 1 2020, In: International journal of molecular sciences. 21, 23, p. 1-16 16 p., 9310.

Research output: Contribution to journalReview articlepeer-review

Decreased parenchymal arteriolar tone uncouples vessel-to-neuronal communication in a mouse model of vascular cognitive impairment

Kim, K. J., Diaz, J. R., Presa, J. L., Muller, P. R., Brands, M. W., Khan, M. B., Hess, D. C., Althammer, F., Stern, J. E. & Filosa, J. A., Jun 2021, In: GeroScience. 43, 3, p. 1405-1422 18 p.

Research output: Contribution to journalArticlepeer-review

A novel heme transporter from the energy coupling factor family is vital for group a streptococcus colonization and infections

Chatterjee, N., Cook, L. C. C., Lyles, K. V., Nguyen, H. A. T., Devlin, D. J., Thomas, L. S. & Eichenbaum, Z., Jul 1 2020, In: Journal of Bacteriology. 202, 14, e00205-20.

Research output: Contribution to journalArticlepeer-review

Transcriptomic analysis of streptococcus pyogenes colonizing the vaginal mucosa identifies hupy, an MtsR-regulated adhesin involved in heme utilization

Cook, L. C. C., Chatterjee, N., Li, Y., Andrade, J., Federle, M. J. & Eichenbaum, Z., May 1 2019, In: mBio. 10, 3, e00848-19.

Research output: Contribution to journalArticlepeer-review

Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases

Gómez-Contreras, P., Ramiro-Díaz, J. M., Sierra, A., Stipp, C., Domann, F. E., Weigel, R. J. & Lal, G., Jan 1 2017, In: Clinical and Experimental Metastasis. 34, 1, p. 37-49 13 p.

Research output: Contribution to journalArticlepeer-review

NADPH oxidase 1 mediates caerulein-induced pancreatic fibrosis in chronic pancreatitis

Xia, D., Halder, B., Godoy, C., Chakraborty, A., Singla, B., Thomas, E., Shuja, J. B., Kashif, H., Miller, L., Csanyi, G. & Sabbatini, M. E., Feb 1 2020, In: Free Radical Biology and Medicine. 147, p. 139-149 11 p.

Research output: Contribution to journalArticlepeer-review

Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan

Kaiser, H., Parker, E. & Hamrick, M. W., Feb 2020, In: Experimental Gerontology. 130, 110797.

Research output: Contribution to journalReview articlepeer-review

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. & McGee-Lawrence, M. E., Feb 2020, In: Experimental Gerontology. 130, 110818.

Research output: Contribution to journalArticlepeer-review

Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin

Folk, W. P., Kumari, A., Iwasaki, T., Pyndiah, S., Johnson, J. C., Cassimere, E. K., Abdulovic-Cui, A. L. & Sakamuro, D., Apr 5 2019, In: Journal of Biological Chemistry. 294, 14, p. 5700-5719 20 p.

Research output: Contribution to journalArticlepeer-review

A potential role for ceramide in the regulation of mouse epidermal keratinocyte proliferation and differentiation

Jung, E., Griner, R. D., Mann-Blakeney, R. & Bollag, W. B., 1998, Journal of Investigative Dermatology. 4 ed. Nature Publishing Group, Vol. 110. p. 318-323 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Augmented astrocyte microdomain Ca 2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice

Diaz, J. R., Kim, K. J., Brands, M. W. & Filosa, J. A., Mar 2019, In: Glia. 67, 3, p. 551-565 15 p.

Research output: Contribution to journalArticlepeer-review

Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment

Rausch, V., Liu, L., Apel, A., Rettig, T., Gladkich, J., Labsch, S., Kallifatidis, G., Kaczorowski, A., Groth, A., Gross, W., Gebhard, M. M., Schemmer, P., Werner, J., Salnikov, A. V., Zentgraf, H., Büchler, M. W. & Herr, I., Jul 2012, In: Journal of Pathology. 227, 3, p. 325-335 11 p.

Research output: Contribution to journalArticlepeer-review

The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation

Salazar, N., Muñoz, D., Kallifatidis, G., Singh, R. K., Jordà, M. & Lokeshwar, B. L., Aug 28 2014, In: Molecular cancer. 13, 1, 198.

Research output: Contribution to journalArticlepeer-review

Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling

Kallifatidis, G., Rausch, V., Baumann, B., Apel, A., Beckermann, B. M., Groth, A., Mattern, J., Li, Z., Kolb, A., Moldenhauer, G., Altevogt, P., Wirth, T., Werner, J., Schemmer, P., Büchler, M. W., Salnikov, A. V. & Herr, I., Jul 2009, In: Gut. 58, 7, p. 949-963 15 p.

Research output: Contribution to journalArticlepeer-review

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Kallifatidis, G., Hoy, J. J. & Lokeshwar, B. L., Oct 1 2016, In: Seminars in Cancer Biology. 40_41, p. 160-169 10 p.

Research output: Contribution to journalReview articlepeer-review

View all Publications

Research News

A group of people stand around a poster pinned to a moveable board. A college woman is talking to the group and pointing to pictures and graphs on the board.

STAR Program opens research pathways for undergrads

Read story
Two college students work with a professor while writing on a white board in a classroom.

Physics faculty publishes article in Nature family of journals

Read story
photo from article Augusta University researcher named to 2023 Class of Fellows for the National Academy of Inventors

Augusta University researcher named to 2023 Class of Fellows for the National Academy of Inventors

Read story

An Education Like No Other

The College of Science and Mathematics provides students with strong foundations in the sciences as well as preparation for careers, citizenship, and a life-long love of learning. We are committed to providing experiences promoting scientific inquiry and discovery and dedicated to creating opportunities for intellectual growth and community involvement.