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- Comparing number of injection sites of in-office intravesical Onabotulinumtoxin A treatments for overactive bladder: a randomized controlled trial
Clinical Trial
Comparing number of injection sites of in-office intravesical Onabotulinumtoxin A treatments for overactive bladder: a randomized controlled trial
Overactive bladder (OAB) is a chronic medical problem that causes a frequent, sudden, and uncontrollable urge to urinate. The need to urinate may occur eight or more times a day, be more severe at night, and can result in leakage of urine. These symptoms occur because the muscles of the bladder start contracting even when the volume of urine sitting in the bladder is low. OAB can greatly impact one?s day to day life due to fear of leakage. Management can include things like changes in diet, timed urination, and bladder holding techniques. If these techniques are not helpful enough, there are many additional treatment options available. One common and effective treatment option includes injecting medication into the muscle of the bladder, the detrusor muscle, to help it relax. This medication is onabotulinumtoxin A, more commonly known as Botox. Botox blocks the nerve signaling to the detrusor muscle that triggers OAB. This not only reduces the frequency of urges, but also provides more time to get to the bathroom. Typically, this medication is injected in the clinic with 20 small injections into the bladder wall. Despite local anesthesia, patients can feel discomfort with each injection. This study aims to determine if using the same amount of medication divided into significantly fewer injections will increase patient satisfaction and decrease procedure pain.
Eligibility Criteria
- Inclusion criteria will consist of females, adults 18 years of age and older, who are diagnosed with OAB. Exclusion criteria will consist of patients who have previously received intravesical onabotulinumtoxin A injections in-office or under general anesthesia, patients who are found to have bladder pathology including nephrolithiasis, active urinary tract infection, bladder trauma, patients with neurogenic bladder, pregnant patients.