Study Enrollment


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Clinical Trial

Autonomic Nervous System Response to Transcranial Magnetic Stimulation in those with Major Depressive Disorder (ANS-TMS)

This study is being done to help the researchers gain experience in measuring the effects of repetitive transcranial magnetic stimulation (rTMS) on the heart rate, called heart rate variability (HRV) and pupillary size, called pupillometry (PLR) in depressed patients. The data will be used for future studies and grant submissions. Participants will be between the ages of 18 -75 and a total of 30 people will be enrolled in the study. During the first visit participants will complete brief questionnaires and cognitive assessments, followed by the HRV and PLR measurements and rTMS stimulations. Over the next four weeks the questionnaires and assessments will be repeated once per week to measure the participant's progress. HRV will be measured before and during one weekly rTMS session. At the end of six weeks of treatment the questionnaires and assessments will be repeated for the final time.


Eligibility Criteria

  • Inclusion Criteria - Adults 18-75 years of age with a diagnosis of major depressive disorder (MDD) who have been approved to receive a course of Repetitive transcranial magnetic stimulation (rTMS). Exclusion Criteria - The use of any prescription or illicit drugs or any over the counter medications with strong effects on the body system that controls heart rate and pupil responses. The presence of any significant eye disease A history of seizure disorder, or other risk factors for rTMS therapy, as determined by the research doctor.

Contact Information

    Peter Rosenquist

    (706) 721-8783

   Prosenquist@augusta.edu

RESEARCH. INNOVATION. DISCOVERY.