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Clinical Trial

Assessment and Validation of Electronic Gas and Bloating Diary

Gas-related symptoms (GRS) such as abdominal bloating, flatulence, and belching are some of the most common gastrointestinal complaints reported by the general population. They are hallmark symptoms in patients with functional gut disorders like irritable bowel syndrome but have also been linked to conditions such as gut hypersensitivity, altered gut microbiota, and altered gut motility and SIBO. Our objective here is to improve documentation and accurate recording of patient-reported symptoms of gas, bloating and distension and other coexisting GI symptoms by utilizing a mobile phone application that interactively records pertinent symptoms. Such an electronic diary will allow us to collect data using objective scoring measures to track progress and obviate the need to rely on a patient's recall of symptoms that are usually flowed due to recall bias. The app will not only be useful in day-to-day clinical practice but also serve as a database for conducting larger population-based studies of food intolerance or small intestinal bacterial overgrowth (SIBO) and/or therapeutic intervention. We will validate the APP against a paper form diary and evaluate its reproducibility and functionality and user-friendliness.

Eligibility Criteria

  • Inclusion/Exclusion for gas and bloating subjects: Inclusion: 1. Anyone 18 years or older with gas-related symptoms (GRS) such as gas and bloating, plus any of the following: distension, diarrhea, and/ or abdominal discomfort. Normal upper endoscopy, normal colonoscopy ( Exclusion: Women of childbearing age will be asked if they are pregnant, and a negative responsewill be sufficient. No pregnancy test will be performed. History of previous GI surgeries (except for cholecystectomy, hysterectomy, and appendectomy) Significant co-morbid medical conditions, including stroke, COPD( Chronic Obstructive Pulmonary Disease) and cancers (except for non-melanotic skin cancer) Recent hospitalization within 30 days of enrollment in this study Recent History (within 4 weeks) of antibiotic use Recent History (within one week) of a colonoscopy or barium study Inclusion/Exclusion for healthy subjects: Inclusion: Anyone 18 years or older with no medical problems and a negative bowel disease screening questionnaire.

Contact Information

    Yun Yan

    (706) 446-5765