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Avatrombopag is an investigational medicine being tested for the prevention of low platelets, and is not commercially available. During this study, staff will follow each participant's need for platelet transfusions and chemotherapy delays or dose reductions to control low platelets, to find out if patients who take the study drug need fewer transfusions and delays than patients who do not take the study drug. In addition, they will follow each patient's health to find out more about the safety of avatrombopag. The study will also test how the study drug is processed by the body, such as how quickly the study drug gets into the blood, how the study drug is broken down by the body.