Dr. Shaoyong Su
Shaoyong Su, PhD
About Shaoyong Su, PhD
As a genetic epidemiologist, my major areas of interest and research are mental and cardiovascular health, the underlying genetic/epigenetic mechanisms, and psychosocial determinants of chronic diseases. My most recent research focuses on the risk factors in early life, including physiological factors (e.g. excessive adiposity and elevated blood pressure in children) and psychosocial factors (e.g. adverse childhood experiences), and their effects on mental, vascular, and cognition health in adulthood, as well as aging health.
Education & Credentials
Postdoctoral - Emory University School of Medicine, Atlanta, GA, 2009
Cardiology
PhD - Fu Wai Hospital & Cardiovascular Institute
Peking Union Medical College & Chinese Academy of Medical Sciences, 2005
Genetic Epidemiology
BS - Beijing Normal University, Beijing, 2005
Computer Science
Publications
Recent Pure Research Publications
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Impact of psychosocial stress in early life on pace of aging in young adulthoodSu, S., Lewis, T. T., Belsky, D. W., Liu, Y., Zhang, K., Snieder, H. & Wang, X., Dec 2025, In: Clinical epigenetics. 17, 1, 186.Research output: Contribution to journal › Article › peer-review |
fMRI-based data-driven brain parcellation using independent component analysisReeves, W. D., Ahmed, I., Jackson, B. S., Sun, W., Williams, C. F., Davis, C. L., McDowell, J. E., Yanasak, N. E., Su, S. & Zhao, Q., May 2025, In: Journal of Neuroscience Methods. 417, 110403.Research output: Contribution to journal › Article › peer-review |
A longitudinal study of blood pressure circadian rhythm from childhood to early adulthoodMassengale, K., Xu, Y., Snieder, H., Su, S. & Wang, X., May 2024, In: Journal of Human Hypertension. 38, 5, p. 437-443 7 p.Research output: Contribution to journal › Article › peer-review |
Nocturnal blood pressure dipping, blood pressure variability, and cognitive function in early and middle-aged adultsMassengale, K., Barnes, V. A., Williams, C., Mansuri, A., Norland, K., Altvater, M., Bailey, H., Harris, R. A., Su, S. & Wang, X., Mar 2024, In: Journal of Clinical Hypertension. 26, 3, p. 235-240 6 p.Research output: Contribution to journal › Article › peer-review |
Racial disparities in the relationship of regional socioeconomic status and colorectal cancer survival in the five regions of GeorgiaTsai, M. H., Vernon, M., Su, S., Coughlin, S. S. & Dong, Y., Feb 2024, In: Cancer Medicine. 13, 3, e6954.Research output: Contribution to journal › Article › peer-review |
Age, sex and race distribution of accelerometer-derived sleep variability in US school-aged children and adultsPrice, E., Li, X., Xu, Y., Mansuri, A., McCall, W. V., Su, S. & Wang, X., Dec 2023, In: Scientific reports. 13, 1, 22114.Research output: Contribution to journal › Article › peer-review |
Sleep Variability, Sleep Irregularity, and Nighttime Blood Pressure DippingXu, Y., Barnes, V. A., Harris, R. A., Altvater, M., Williams, C., Norland, K., Looney, J., Crandall, R., Su, S. & Wang, X., Dec 1 2023, In: Hypertension. 80, 12, p. 2621-2626 6 p.Research output: Contribution to journal › Article › peer-review |
Day-to-day deviations in sleep parameters and biological aging: Findings from the NHANES 2011-2014Wang, X., Xu, Y., Li, X., Mansuri, A., McCall, W. V., Liu, Y. & Su, S., Dec 2023, In: Sleep Health. 9, 6, p. 940-946 7 p.Research output: Contribution to journal › Article › peer-review |
Characterization of Resting-State Functional Connectivity Changes in Hypertension by a Modified Difference Degree TestReeves, W. D., Ahmed, I., Jackson, B. S., Sun, W., Brown, M. L., Williams, C. F., Davis, C. L., McDowell, J. E., Yanasak, N. E., Su, S. & Zhao, Q., Nov 1 2023, In: Brain Connectivity. 13, 9, p. 563-573 11 p.Research output: Contribution to journal › Article › peer-review |
Blunted rest-activity circadian rhythm increases the risk of all-cause, cardiovascular disease and cancer mortality in US adultsXu, Y., Su, S., Li, X., Mansuri, A., McCall, W. V. & Wang, X., Dec 2022, In: Scientific reports. 12, 1, p. 20665 20665.Research output: Contribution to journal › Article › peer-review |
Neuropsychiatric sequelae of long COVID-19: Pilot results from the COVID-19 neurological and molecular prospective cohort study in Georgia, USAChen, A. K., Wang, X., McCluskey, L. P., Morgan, J. C., Switzer, J. A., Mehta, R., Tingen, M., Su, S., Harris, R. A., Hess, D. C. & Rutkowski, E. K., Oct 2022, In: Brain, Behavior, and Immunity - Health. 24, 100491.Research output: Contribution to journal › Article › peer-review |
Blunted rest-activity circadian rhythm is associated with increased rate of biological aging: an analysis of NHANES 2011-2014Xu, Y., Wang, X., Belsky, D. W., McCall, W. V., Liu, Y. & Su, S., Sep 18 2022, In: The journals of gerontology. Series A, Biological sciences and medical sciences.Research output: Contribution to journal › Article › peer-review |
Epidemiology of accelerometer-based sleep parameters in US school-aged children and adults: NHANES 2011–2014Su, S., Li, X., Xu, Y., McCall, W. V. & Wang, X., May 10 2022, In: Scientific reports. 12, 1, p. 7680 7680.Research output: Contribution to journal › Article › peer-review |
Blunted rest-activity rhythm is associated with increased white blood-cell-based inflammatory markers in adults: an analysis from NHANES 2011-2014Xu, Y., Su, S., McCall, W. V. & Wang, X., Mar 9 2022, In: Chronobiology International. p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review |
Rest-activity circadian rhythm and impaired glucose tolerance in adults: an analysis of NHANES 2011-2014Xu, Y., Su, S., McCall, W. V., Isales, C., Snieder, H. & Wang, X., Mar 1 2022, In: BMJ Open Diabetes Research and Care. 10, 2Research output: Contribution to journal › Article › peer-review |
Potential transgenerational epigenetic effects of prolonged stress and psychological traumaYoussef, N. A., Lockwood, L., Su, S., Hao, G. & Rutten, B. P. F., Jan 1 2022, Epigenetics of Stress and Stress Disorders. Elsevier, p. 307-315 9 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Epigenetics, stress, and depressionLockwood, L., Su, S. & Youssef, N. A., Jan 1 2022, Epigenetics of Stress and Stress Disorders. Elsevier, p. 225-238 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter |
Ethnic differences and heritability of blood pressure circadian rhythmin African and European American youth and young adultsXu, Y., Su, S., Brown, M., Snieder, H., Harshfield, G. A. & Wang, X., Jan 1 2022, In: Journal of hypertension. 40, 1, p. 163-170 8 p.Research output: Contribution to journal › Article › peer-review |
Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthoodHuang, Y., Su, S., Snieder, H., Treiber, F., Kapuku, G. & Wang, X., Apr 26 2021, In: Scientific reports. 11, 1, p. 8911 1 p.Research output: Contribution to journal › Article › peer-review |
Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac massHao, G., Halbert, J., Su, S., Bagi, Z., Robinson, V., Thayer, J., Harshfield, G. A. & Kapuku, G., 2021, In: Acta Cardiologica. 76, 10, p. 1117-1123 7 p.Research output: Contribution to journal › Article › peer-review |
Diurnal cortisol slope and nighttime bloodpressure: Astudy in european Americans and African AmericansErnst, B., Su, S., Treiber, F., Snieder, H. & Wang, X., 2021, In: Ethnicity and Disease. 31, 4, p. 481-488 8 p.Research output: Contribution to journal › Article › peer-review |
High-mobility group box-1 is associated with obesity, inflammation, and subclinical cardiovascular risk among young adults a longitudinal cohort study: A Longitudinal Cohort StudyChen, L., Zhu, H., Su, S., Harshfield, G. A., Sullivan, J., Webb, C., Blumenthal, J. A., Wang, X., Huang, Y., Treiber, F. A., Kapuku, G., Li, W. & Dong, Y., Nov 2020, In: Arteriosclerosis, thrombosis, and vascular biology. 40, 11, p. 2776-2784 9 p.Research output: Contribution to journal › Article › peer-review |
Effectiveness of social cognitive theory-based interventions for glycemic control in adults with type 2 diabetes mellitus: Protocol for a systematic review and meta-analysisSmith, Y., Garcia-Torres, R., Coughlin, S. S., Ling, J., Marin, T., Su, S. & Young, L., Sep 2020, In: JMIR Research Protocols. 9, 9, p. e17148 e17148.Research output: Contribution to journal › Review article › peer-review |
Identification, Heritability, and Relation with Gene Expression of Novel DNA Methylation Loci for Blood PressureHuang, Y., Ollikainen, M., Muniandy, M., Zhang, T., Van Dongen, J., Hao, G., Van Der Most, P. J., Pan, Y., Pervjakova, N., Sun, Y. V., Hui, Q., Lahti, J., Fraszczyk, E., Lu, X., Sun, D., Richard, M. A., Willemsen, G., Heikkila, K., Mateo Leach, I. & Mononen, N. & 32 others, , Jul 1 2020, In: Hypertension. 76, 1, p. 195-205 11 p.Research output: Contribution to journal › Article › peer-review |
Serum 25-hydroxyvitamin D concentrations are associated with mental health and psychosocial stress in young adultsChen, L., Zhu, H., Harshfield, G. A., Treiber, F. A., Pollock, J. S., Pollock, D., Okereke, O. I., Su, S. & Dong, Y., Jul 2020, In: Nutrients. 12, 7, p. 1-12 12 p., 1938.Research output: Contribution to journal › Article › peer-review |
Cigarette smoking related DNA methylation in peripheral leukocytes and cardiovascular risk in young adultsSabogal, C., Su, S., Tingen, M., Kapuku, G. & Wang, X., May 1 2020, In: International Journal of Cardiology. 306, p. 203-205 3 p.Research output: Contribution to journal › Article › peer-review |
Social Determinants of Cardiovascular Health: Early Life Adversity as a Contributor to Disparities in Cardiovascular DiseasesSuglia, S. F., Campo, R. A., Brown, A. G. M., Stoney, C., Boyce, C. A., Appleton, A. A., Bleil, M. E., Boynton-Jarrett, R., Dube, S. R., Dunn, E. C., Ellis, B. J., Fagundes, C. P., Heard-Garris, N. J., Jaffee, S. R., Johnson, S. B., Mujahid, M. S., Slopen, N., Su, S. & Watamura, S. E., Apr 2020, In: Journal of Pediatrics. 219, p. 267-273 7 p.Research output: Contribution to journal › Comment/debate › peer-review |
Genetic and environmental influences on blood pressure and body mass index in the national academy of sciences-national research council world war II veteran twin registryWang, B., Wu, T., Neale, M. C., Verweij, R., Liu, G., Su, S. & Snieder, H., 2020, (Accepted/In press) In: Hypertension. p. 1428-1434 7 p.Research output: Contribution to journal › Article › peer-review |
Discovery and Validation of a Novel Neutrophil Activation Marker Associated with ObesityPan, Y., Choi, J.-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In: Scientific reports. 9, 1, 3433.Research output: Contribution to journal › Article › peer-review |
Ethnic differences in nighttime melatonin and nighttime blood pressure: A study in European Americans and African AmericansJeong, J., Zhu, H., Harris, R. A., Dong, Y., Su, S., Tingen, M. S., Kapuku, G., Pollock, J. S., Pollock, D. M., Harshfield, G. A. & Wang, X., Nov 1 2019, In: American journal of hypertension. 32, 10, p. 968-974 7 p.Research output: Contribution to journal › Article › peer-review |
Body mass index drives changes in DNA methylation: A longitudinal studySun, D., Zhang, T., Su, S., Hao, G., Chen, T., Li, Q. Z., Bazzano, L., He, J., Wang, X., Li, S. & Chen, W., Oct 11 2019, In: Circulation research. 125, 9, p. 824-833 10 p.Research output: Contribution to journal › Article › peer-review |
Determinants of pulse wave velocity trajectories from youth to young adulthood: The Georgia Stress and Heart StudyLiang, X., Su, S., Hao, G., Snieder, H., Treiber, F., Kapuku, G. & Wang, X., Mar 2019, In: Journal of hypertension. 37, 3, p. 563-571 9 p.Research output: Contribution to journal › Article › peer-review |
Longitudinal association of inflammation with depressive symptoms: A 7-year cross-lagged twin difference studyHuang, M., Su, S., Goldberg, J., Miller, A. H., Levantsevych, O. M., Shallenberger, L., Pimple, P., Pearce, B., Bremner, J. D. & Vaccarino, V., Jan 2019, In: Brain, Behavior, and Immunity. 75, p. 200-207 8 p.Research output: Contribution to journal › Article › peer-review |
Associations between muscle mass, physical activity and dietary behavior in adolescentsHao, G., Pollock, N. K., Harris, R. A., Gutin, B., Su, S. & Wang, X., Aug 2018, In: Pediatric Obesity.Research output: Contribution to journal › Article › peer-review |
Association of depressive symptoms and heart rate variability in Vietnam war-era twins: A longitudinal twin difference studyHuang, M., Shah, A., Su, S., Goldberg, J., Lampert, R. J., Levantsevych, O. M., Shallenberger, L., Pimple, P., Bremner, J. D. & Vaccarino, V., Jul 2018, In: JAMA Psychiatry. 75, 7, p. 705-712 8 p.Research output: Contribution to journal › Article › peer-review |
The effects of trauma, with or without PTSD, on the transgenerational DNA methylation alterations in human offspringsYoussef, N. A., Lockwood, L., Su, S., Hao, G. & Rutten, B. P. F., May 2018, In: Brain Sciences. 8, 5, 83.Research output: Contribution to journal › Review article › peer-review |
Body mass index trajectories in childhood is predictive of cardiovascular risk: Results from the 23-year longitudinal Georgia Stress and Heart studyHao, G., Wang, X., Treiber, F. A., Harshfield, G., Kapuku, G. & Su, S., Apr 1 2018, In: International Journal of Obesity. 42, 4, p. 923-925 3 p.Research output: Contribution to journal › Article › peer-review |
The role of DNA methylation in the association between childhood adversity and cardiometabolic diseaseHao, G., Youssef, N. A., Davis, C. L. & Su, S., Mar 15 2018, In: International Journal of Cardiology. 255, p. 168-174 7 p.Research output: Contribution to journal › Article › peer-review |
An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expressionWang, X., Pan, Y., Zhu, H., Hao, G., Huang, Y., Barnes, V., Shi, H., Snieder, H., Pankow, J., North, K., Grove, M., Guan, W., Demerath, E., Dong, Y. & Su, S., 2018, In: Clinical epigenetics. 10, p. 3 1 p.Research output: Contribution to journal › Article › peer-review |
Genetic and environmental effects on gene expression signatures of blood pressure: A transcriptome-wide twin studyHuang, Y., Ollikainen, M., Sipil, P., Mustelin, L., Wang, X., Su, S., Huan, T., Levy, D., Wilson, J., Snieder, H., Kaprio, J. & Wang, X., 2018, In: Hypertension. 71, 3, p. 457-464 8 p.Research output: Contribution to journal › Article › peer-review |
Honors & Awards
2007
2008
Postdoctoral Research Symposium Best Poster Award, Emory University
2008
Postdoctoral Merit Award, Emory University
2009
2009
2012
2013
2022
Projects
Psychosocial Stress, Epigenetics, & Health Disparity in Hypertension
1R01MD013307 (S. Su/ F. Treiber)
August 2019 through May 2025
NIH/NIMHD $2,987,927
Role: Principal Investigator
This project aims to find how epigenetic mediates the effect of chronic stress on the risk of essential hypertension and its related racial disparity.
Pediatric Ambulatory Blood Pressure Trajectory & Brain Health in Midlife
1R01HL143440-01A1 (S. Su / J. McDowell)
June 2019 through April 2024
NIH/NHLBI $2,845,194
Role: Principal Investigator
This project will examine the impact of elevated BP during early life on brain health in midlife. It will aid in the identification of key factors, timing and subpopulation to target for developing novel prevention and intervention strategies at an early stage that could slow the progression of aging process in vasculature and brain, eventually averting accelerated cognitive decline in late life.
Epigenetic Response to Early Life Stress and the Impact on Cardiovascular Health
1R01HL125577-01 (S. Su)
May 2015 through April 2020
NIH/NHLBI $379,583
Role: Principal Investigator
The major objective is to identify ELS-related DNA methylation modifications in early young adulthood and to examine their varies and impacts on cardiovascular health over time.