Yisang Yoon


Yisang Yoon


Academic Appointment(s)

Medical College of Georgia
Department of Physiology

The Graduate School


  • Ph.D., Molecular Genetics Ohio State University, 1993

  • MS, Microbiology, General Seoul National University, 1984

  • BS, Microbiology, General Seoul National University, 1982

Courses Taught Most Recent Academic Year

  • BIOM 8021

    Biochem & Gene Regulation
  • MEDI 6300

    Career Paths in Med
  • PSIO 9210

    Invest of a Problem
  • PSIO 9300

  • BIOM 8011

    Respon Conduct of Research
  • PSIO 9010

    Seminar in Physiology


Selected Recent Publications

  • The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury, 2023
    Journal Article, Academic Journal
  • Non-conventional mitochondrial permeability transition: Its regulation by mitochondrial dynamics., 2022
    Journal Article, Academic Journal
  • Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouse., 2022
    Journal Article, Academic Journal
  • Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation., 2021
    Journal Article, Academic Journal
  • Comparison Between an Intraocular Lens With Extended Depth of Focus (Tecnis Symfony ZXR00) and a New Monofocal Intraocular Lens With Enhanced Intermediate Vision (Tecnis Eyhance ICB00)., 2021
    Journal Article, Academic Journal

Research Interests

My laboratory studies mitochondria, critical cellular organelles that produce most of the cellular energy. Mitochondria are specially equipped to produce chemical energy required for cellular processes. This energy-producing process involves carefully controlled electron transport within mitochondria. However, when this process is perturbed, electrons can uncontrollably react with oxygen molecules to produce oxygen radicals that can be further converted to various highly reactive toxic chemical compounds called reactive oxygen species (ROS). Mitochondria contain elaborately organized internal structures encapsulated in dynamically changing tubular networks. This dynamic shape change is mediated by fission and fusion of membrane tubules. Our research focus is to define the molecular mechanisms of mitochondrial shape change and to understand physiological significance of mitochondrial dynamics. Our studies have found that mitochondrial shape change is a key element participating in regulation of mitochondrial electron transport and ROS production.

Department Service

  • Director Physiology Graduate Program 2019 - Present

    Role: Other
  • Graduate Education Committee 2018 - Present

    Role: Committee Chair
  • Department of Physiology Graduate Education Committee 2013 - Present

    Role: Committee Member
  • Department of Physiology Faculty Search Committee 2013 - 2017

    Role: Committee Member

University Service

  • MCG Faculty Senate Faculty Recognition Committee 2019 - Present

    Role: Committee Member

Professional Service

  • American Heart Association, MSO study section 2017 - Present

    Role: Committee Member
  • American Heart Association Fellowships Basic Science 3 - 2021

    Role: Reviewer
  • American Physiological Society “Physiological Bioenergetics: Mitochondria”, Organizing committee - 2017

    Role: Committee Member
  • Antioxidants, “Mitochondrial Shape Change in Physio-pathology” - 2017

    Role: Other
  • Diabetes UK, project Grant - 2016

    Role: Reviewer, Grant Proposal