Matteo Borgini

Assistant Professor

Matteo Borgini

Assistant Professor

Academic Appointment(s)

Administration
Department of Chemistry and Biochemistry

College of Science and Mathematics
Department of Chemistry and Biochemistry

Bio

Dr. Borgini graduated from the University of Siena, Italy, in 2015 and received his PhD in Chemical and Pharmaceutical Sciences under the supervision of Professor Maurizio Botta. During his PhD studies he worked on the synthesis of epigenetic modulators as anticancer agents, host protein inhibitors as antiviral compounds, and developed new antifungal drugs. He then pursued his Postdoctoral studies with Professor Peter Wipf at the University of Pittsburgh, USA. During that time, Dr. Borgini developed new ways to access fluorinated as well as 13C-labeled amino acids exploiting C-H functionalization, complex heterocyclic compounds by transition-metal catalyzed annulative cleavage of bicyclo[1.1.0]butane dihydroquinolines and dihydropyridines, and developed mitochondria-targeted PARP-1 inhibitor prodrugs as potential neuroprotective agents. Dr. Borgini started his independent career at Augusta University, USA, as Assistant Professor in Medicinal Chemistry at the Department of Chemistry and Biochemistry. The Drug Discovery campaigns in the Borgini Lab are aimed to find new ways to chemically modulate biological targets considered "difficult to drug", advancing new medicinal chemistry tools including Protein-Protein interaction Inhibitors and Covalent Inhibitors.