Jie Li

Assistant Professor

Jie Li

Assistant Professor

Academic Appointment(s)

Medical College of Georgia
Department of Pharmacology and Toxicology

Medical College of Georgia
Department of Medicine: Cardiology

The Graduate School

Department of The Graduate School


Jie Li is currently Assistant Professor at the Vascular Biology Center. Her research interest is to understand how to prevent and treat heart failure.


  • Ph.D., Biomedical Sciences, General University of South Dakota, 2008

Awards & Honors

  • Junior faculty award, 1st place ACRE-APS Research Symposium, 2020

  • New Investigator Travel Award of the Basic Cardiovascular Sciences Conference American Heart Association, 2011

  • Poster Award of the Protein Quality Control Symposium University of South Dakota, 2011

  • University of South Dakota Graduate Research Grant University of South Dakota, 2005

Courses Taught Most Recent Academic Year

  • VBIO 9210

    Investigation of a Prob
  • VBIO 8010

    Methods in Cardiovascular Rese
  • BIOM 8130

    Scientific Grant Writing

Teaching Interests

Jie Li is dedicated to fostering the next generation of scientists in the classroom and laboratory setting and also involved in teaching graduate and medical students a number of different courses.


Selected Recent Publications

  • Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress Response, Embryonic Development, and Cardiac and Intestinal Homeostasis, 2023
  • Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation, 2023
    Journal Article, Academic Journal
  • BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism., 2022
    Journal Article, Academic Journal
  • TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes., 2021
    Journal Article, Academic Journal
  • Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction., 2020
    Journal Article, Academic Journal

Research Interests

Maintenance of a functional proteome is integral to cardiomyocyte function and survival. Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins are crucial regulators of protein quality and function through post-translational modification of their diverse substrates. To date, how Ub and Ubl-mediated PTMs control the function and survival of cardiomyocytes, or how dysregulation of such PTMs contributes to the development of cardiomyopathy and heart failure, remains poorly understood. My research aims to understand the molecular basis by which Ub and Ubls regulate the structure and function of cardiac muscle tissue, and ultimately to uncover novel therapeutic targets and strategies to prevent and treat cardiac disease.

Department Service

  • Ecocardiography machine staorage maintenace 2021 - Present

    Role: Other