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This study proposes to develop a novel treatment for Parkinson?s disease (PD) using gangliosides. Our team found that gangliosides can prevent the accumulation of a toxic protein to keep dopaminergic neurons functioning properly. We also want to examine that those gangliosides can regenerate the dopamine-producing cells within the brain. Our long-term goal is to develop the ganglioside therapy as an effective disease-modifying treatment for PD and other similar brain diseases.